Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family

Hassnae Afrache (1) , Pierre Pontarotti (2) , Laurent Abi-Rached (3) , Daniel Olive (4)

1 LATP - Laboratoire d'Analyse, Topologie, Probabilités
2 I2M - Institut de Mathématiques de Marseille
3 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
4 CRCM - Centre de Recherche en Cancérologie de Marseille

(230 words) 16 The butyrophilin 3 (BTN3) are receptors of the immunoglobulin superfamily implicated in the T 17 lymphocytes regulation and present a wide plasticity in mammals, being absent in rodent but 18 present with three copies in human. In order to understand how these genes have been diversified 19 and what forces guiding this diversification, we studied their evolution and show that the three 20 human BTN3 genes are the result of two successive duplications in Primates and that the three 21

Domaines: Sciences du Vivant [q-bio]; Biologie moléculaire; Immunologie; Bio-Informatique, Biologie Systémique [q-bio.QM]

Hassnae Afrache, Pierre Pontarotti, Laurent Abi-Rached, Daniel Olive. Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family. Immunogenetics, 2017, 69 (6), pp.379 - 390. ⟨10.1007/s00251-017-0980-z⟩. ⟨hal-01785307⟩