Circulating Cell Free Tumor DNA Detection as a Routine Tool forLung Cancer Patient Management

Julie A Vendrell (1) , Frédéric Tran Mau-Them (1) , Benoît Beganton (2, 3) , Sylvain Godreuil (4) , Peter Coopman (2, 3) , Jérôme Solassol (1, 2)

1 Service de Biopathologie [CHRU Montpellier]
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 ICM - UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Circulating tumoral DNA (ctDNA), commonly named "liquid biopsy", has emerged as a new promising noninvasive tool to detect biomarker in several cancers including lung cancer. Applications involving molecular analysis of ctDNA in lung cancer have increased and encompass diagnosis, response to treatment, acquired resistance and prognosis prediction, while bypassing the problem of tumor heterogeneity. ctDNA may then help perform dynamic genetic surveillance in the era of precision medicine through indirect tumoral genomic information determination. The aims of this review were to examine the recent technical developments that allowed the detection of genetic alterations of ctDNA in lung cancer. Furthermore, we explored clinical applications in patients with lung cancer including treatment efficiency monitoring, acquired therapy resistance mechanisms and prognosis value.

Mots clés: circulating DNA; lung cancer; molecular diagnosis; routine practice; targeted therapies

Domaines: Cancer; Biochimie [q-bio.BM]

Julie A Vendrell, Frédéric Tran Mau-Them, Benoît Beganton, Sylvain Godreuil, Peter Coopman, et al.. Circulating Cell Free Tumor DNA Detection as a Routine Tool forLung Cancer Patient Management. International Journal of Molecular Sciences, 2017, 18 (2), pp.264. ⟨10.3390/ijms18020264⟩. ⟨hal-01784728⟩