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Communication Dans Un Congrès Année : 2017

Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study

Résumé

To determine the metabolic counterparts of cerebral total sodium accumulations in patients with Multiple Sclerosis, we acquired fast 3D-^\textrm1H-EPSI and Density-adapted 3D-UTE ^\textrm23Na MRI at 3 Tesla covering the whole brain in 21 patients and 20 volunteers. Patients showed increased ^\textrm23Na and decreased NAA, Glx and Cho levels. Stepwise analyses highlights association of ^\textrm23Na accumulations with i) decreased NAA and Glx levels and increased Cho levels within GM, ii) with decreased NAA and increased Cho levels within NAWM and T_\textrm2 lesion compartments. Clinical status of patients assessed by MSFC was correlated to GM and NAWM ^\textrm23Na, NAA and Glx levels.
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Dates et versions

hal-01784683 , version 1 (03-05-2018)

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  • HAL Id : hal-01784683 , version 1

Citer

Maxime Donadieu, Adil Maarouf, Yann Le Fur, Soraya Gherib, Elisabeth Soulier, et al.. Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study. Proc. Intl. Soc. Mag. Reson. Med. 25, 2017, Unknown, Unknown Region. pp.0212. ⟨hal-01784683⟩
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