Supercritical CO2 antisolvent process for drugs precipitation : from lab-scale to cGMP compliant pilot-scale

S. Papet (1) , Florence Marciacq (2) , Hubert Lochard (3) , Martial Sauceau (3) , Christophe Joussot Dubien (1) , B. Freiss (2) , S. Sarrade (1)

1 CEA - CEA VALRHO
2 Centre de R&D Pierre Fabre - Centre de Recherche Pierre Fabre
3 Poudres et procédés - Ecole des Mines Albi-Carmaux

Domaines: Pharmacie galénique; Génie des procédés

S. Papet, Florence Marciacq, Hubert Lochard, Martial Sauceau, Christophe Joussot Dubien, et al.. Supercritical CO2 antisolvent process for drugs precipitation : from lab-scale to cGMP compliant pilot-scale. 6th International symposium on supercritical fluids, Apr 2003, Versailles, France. pp.1689-1694. ⟨hal-01781685⟩