Extended spectrum of antibiotic susceptibility for tuberculosis, Djibouti

Feriel Bouzid (1, 2) , Helene Astier (3) , Djaltou Aboubaker Osman , Emilie Javelle (4, 5) , Mohamed Osman Hassan , Fabrice Simon (6) , Eric Garnotel (6, 5) , Michel Drancourt (7)

1 URMITE - Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes
2 EIPL - Enzymologie interfaciale et de physiologie de la lipolyse
3 PC - Plasticité cérébrale
4 Département des Maladies infectieuses [Marseille]
5 VITROME - Vecteurs - Infections tropicales et méditerranéennes
6 Hôpital d'Instruction des Armées Laveran
7 MEPHI - Microbes évolution phylogénie et infections

In the Horn of Africa, there is a high prevalence of tuberculosis that is reported to be partly driven by multidrug-resistant (MDR) Mycobacterium tuberculosis strictu sensu strains. We conducted a prospective study to investigate M. tuberculosis complex species causing tuberculosis in Djibouti, and their in vitro susceptibility to standard anti-tuberculous antibiotics in addition to clofazimine, minocycline, chloramphenicol and sulfadiazine. Among the 118mycobacteria isolates from 118 successive patients with suspected pulmonary tuberculosis, 111 strains of M. tuberculosis, five Mycobacterium canettii, one `Mycobacterium simulans' and one Mycobacterium kansasii were identified. Drug-susceptibility tests performed on the first 78 isolates yielded nine MDR M. tuberculosis isolates. All isolates were fully susceptible to clofazimine, minocycline and chloramphenicol, and 75 of 78 isolates were susceptible to sulfadiazine. In the Horn of Africa, patients with confirmed pulmonary tuberculosis caused by an in vitro susceptible strain may benefit from anti-leprosy drugs, sulfamides and phenicol antibiotics. (c) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Domaines: Maladies infectieuses

Feriel Bouzid, Helene Astier, Djaltou Aboubaker Osman, Emilie Javelle, Mohamed Osman Hassan, et al.. Extended spectrum of antibiotic susceptibility for tuberculosis, Djibouti. International Journal of Antimicrobial Agents, 2018, 51 (2), pp.235-238. ⟨10.1016/j.ijantimicag.2017.07.007⟩. ⟨hal-01780646⟩