Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Catherine Phelan Karoline Kuchenbaecker Jonathan Tyrer Siddhartha Kar Kate Lawrenson Stacey Winham Joe Dennis Ailith Pirie Marjorie Riggan Ganna Chornokur Madalene Earp Paulo Lyra Jr. Janet Lee Simon Coetzee Jonathan Beesley Lesley Mc Guffog Penny Soucy Ed Dicks Andrew Lee Daniel Barrowdale Julie Lecarpentier Goska Leslie Cora Aalfs Katja Aben Marcia Adams Julian Adlard Irene Andrulis Hoda Anton-Culver Natalia Antonenkova Aocs Study Group Gerasimos Aravantinos Norbert Arnold Banu Arun Brita Arver Jacopo Azzollini Judith Balmaña Susana Banerjee Laure Barjhoux 1 Rosa Barkardottir Yukie Bean Matthias Beckmann Alicia Beeghly-Fadiel Javier Benitez Marina Bermisheva Marcus Bernardini Michael Birrer Line Bjorge Amanda Black Kenneth Blankstein Marinus Blok Clara Bodelon Natalia Bogdanova Anders Bojesen Bernardo Bonanni Åke Borg Angela Bradbury James Brenton Carole Brewer Louise Brinton Per Broberg Angela Brooks-Wilson Fiona Bruinsma Joan Brunet Bruno Buecher 2 Ralf Butzow Saundra Buys Trinidad Caldes Maria Caligo Ian Campbell Rikki Cannioto Michael Carney Terence Cescon Salina Chan Jenny Chang-Claude Stephen Chanock Xiao Qing Chen Yoke-Eng Chiew Jocelyne Chiquette Wendy Chung Kathleen Claes Thomas Conner Linda Cook Jackie Cook Daniel Cramer Julie Cunningham Aimee D'Aloisio Mary Daly Francesca Damiola 1 Sakaeva Dina Damirovna Agnieszka Dansonka-Mieszkowska Fanny Dao Rosemarie Davidson Anna Defazio Capucine Delnatte 3 Kimberly Doheny Orland Diez Yuan Chun Ding Jennifer Anne Doherty Susan Domchek Cecilia Dorfling Thilo Dörk Laure Dossus 4 Mercedes Durán Matthias Dürst Bernd Dworniczak Diana Eccles Todd Edwards Ros Eeles Ursula Eilber Bent Ejlertsen Arif Ekici Steve Ellis Mingajeva Elvira Study Embrace Kevin Eng Christoph Engel D Gareth Evans Peter Fasching Sarah Ferguson Sandra Ferrer 5 James Flanagan Zachary Fogarty Renée Fortner Florentia Fostira William Foulkes George Fountzilas Brooke Fridley Tara Friebel Eitan Friedman Debra Frost Patricia Ganz Judy Garber Maria Garcia Vanesa Garcia-Barberan Andrea Gehrig Gemo Study Collaborators Aleksandra Gentry-Maharaj Anne-Marie Gerdes Graham Giles Rosalind Glasspool Gord Glendon Andrew Godwin David Goldgar Teodora Goranova Martin Gore Mark Greene Jacek Gronwald Stephen Gruber Eric Hahnen Christopher Haiman Niclas Håkansson Ute Hamann Thomas Hansen Patricia Harrington Holly Harris Jan Hauke Hebon Study Alexander Hein Alex Henderson Michelle Hildebrandt Peter Hillemanns Shirley Hodgson Claus Høgdall Estrid Høgdall Frans Hogervorst Helene Holland Maartje Hooning Karen Hosking Ruea-Yea Huang Peter Hulick Jillian Hung David Hunter David Huntsman Tomasz Huzarski Evgeny Imyanitov Claudine Isaacs Edwin Iversen Louise Izatt Angel Izquierdo Anna Jakubowska Paul James Ramunas Janavicius Mats Jernetz Allan Jensen Uffe Birk Jensen Esther M John Sharon Johnatty Michael Jones Päivi Kannisto Beth Karlan Anthony Karnezis Karin Kast Kconfab Investigators Catherine Kennedy Elza Khusnutdinova Lambertus Kiemeney Johanna Kiiski Sung-Won Kim Susanne Kjaer Martin Köbel Reidun Kopperud Torben Kruse Jolanta Kupryjanczyk Ava Kwong Yael Laitman Diether Lambrechts Nerea Larrañaga Melissa Larson Conxi Lazaro Nhu Le Loic Le Marchand Jong Won Lee Shashikant Lele Arto Leminen Dominique Leroux 6 Jenny Lester Fabienne Lesueur 7, 8, 9 Douglas Levine Dong Liang Clemens Liebrich Jenna Lilyquist Loren Lipworth Jolanta Lissowska Karen Lu Jan Lubiński Craig Luccarini Lene Lundvall Phuong Mai Gustavo Mendoza-Fandiño Siranoush Manoukian Leon Massuger Taymaa May Sylvie Mazoyer 10 Jessica Mcalpine Valerie Mcguire John Mclaughlin Iain Mcneish Hanne Meijers-Heijboer Alfons Meindl Usha Menon Arjen Mensenkamp Melissa Merritt Roger Milne Gillian Mitchell Francesmary Modugno Joanna Moes-Sosnowska Melissa Moffitt Marco Montagna Kirsten Moysich Anna Mulligan Jacob Musinsky Katherine Nathanson Lotte Nedergaard Roberta Ness Susan Neuhausen Heli Nevanlinna Dieter Niederacher Robert Nussbaum Kunle Odunsi Edith Olah Olufunmilayo Olopade Håkan Olsson Curtis Olswold David O'Malley Kai-Ren Ong N Charlotte Onland-Moret Opal Study Group Nicholas Orr Sandra Orsulic Ana Osorio Domenico Palli Laura Papi Tjoung-Won Park-Simon James Paul Celeste Pearce Inge Søkilde Pedersen Petra Peeters Bernard Peissel Ana Peixoto Tanja Pejovic Liisa Pelttari Jennifer Permuth Paolo Peterlongo Lidia Pezzani Georg Pfeiler Kelly-Anne Phillips Marion Piedmonte Malcolm Pike Anna Piskorz Samantha Poblete Timea Pocza Elizabeth Poole Bruce Poppe Mary Porteous Fabienne Prieur 11 Darya Prokofyeva Elizabeth Pugh Miquel Angel Pujana Pascal Pujol 12 Paolo Radice Johanna Rantala Christine Rappaport-Fuerhauser Gad Rennert Kerstin Rhiem Patricia Rice Andrea Richardson Mark Robson Gustavo C Rodriguez Cristina Rodríguez-Antona Jane Romm Matti A Rookus Mary Anne Rossing Joseph Rothstein Anja Rudolph Ingo B. Runnebaum Helga Salvesen Dale P Sandler Minouk J. Schoemaker Leigha Senter V. Wendy Setiawan Gianluca Severi 13, 14, 15 Priyanka Sharma Tameka Shelford Nadeem Siddiqui Lucy E Side Weiva Sieh Christian F. Singer Hagay Sobol 16 Honglin Song Melissa C. Southey Amanda B. Spurdle Zsofia Stadler Doris Steinemann Dominique Stoppa-Lyonnet 2 Lara Sucheston-Campbell Grzegorz Sukiennicki Rebecca Sutphen Christian Sutter Anthony Swerdlow Csilla Szabo Lukasz Szafron Yen Tan Jack Taylor Muy-Kheng Tea Manuel R. Teixeira Soo-Hwang Teo Kathryn Terry Pamela Thompson Liv Cecilie Vestrheim Thomsen Darcy Thull Laima Tihomirova Anna Tinker Marc Tischkowitz Silvia Tognazzo Amanda Ewart Toland Alicia Tone Britton Trabert Ruth C. Travis Antonia Trichopoulou Nadine Tung Shelley S Tworoger Anne Van Altena David Van den Berg Annemarie Van Der Hout Rob B Van Der Luijt Mattias Van Heetvelde Els Van Nieuwenhuysen Elizabeth J Van Rensburg Adriaan Vanderstichele Raymonda Varon-Mateeva Vega Ana Digna Velez Edwards Ignace Vergote Robert Vierkant Joseph Vijai Athanassios Vratimos Lisa Walker Christine Walsh Dorothea Wand Shan Wang-Gohrke Barbara Wappenschmidt Penelope Webb Clarice R Weinberg Jeffrey N. Weitzel Nicolas Wentzensen Alice Whittemore Juul T. Wijnen Lynne Wilkens Alicja Wolk Michelle Woo Xifeng Wu Anna Wu Hannah Yang Drakoulis Yannoukakos Argyrios Ziogas Kristin Zorn Steven A. Narod Douglas F Easton Christopher I. Amos Joellen Schildkraut Susan Ramus Laura Ottini Marc Goodman Sue Park Linda Kelemen Harvey A Risch Mads Thomassen Kenneth Offit Jacques Simard Rita Katharina Schmutzler Dennis Hazelett Alvaro Monteiro Fergus J Couch Andrew Berchuck Georgia Chenevix-Trench Ellen Goode Thomas Sellers Simon A Gayther Antonis C Antoniou Paul Pharoah
Abstract : To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
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Article dans une revue
Nature Genetics, Nature Publishing Group, 2017, 49 (5), pp.680-691. 〈10.1038/ng.3826〉
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https://hal.archives-ouvertes.fr/hal-01778538
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Soumis le : mercredi 25 avril 2018 - 17:36:07
Dernière modification le : mardi 17 juillet 2018 - 11:12:02

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Catherine Phelan, Karoline Kuchenbaecker, Jonathan Tyrer, Siddhartha Kar, Kate Lawrenson, et al.. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics, Nature Publishing Group, 2017, 49 (5), pp.680-691. 〈10.1038/ng.3826〉. 〈hal-01778538〉

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