, Molho M (University Hospital of La Réunion

F. Clarençon and V. Degos,

M. Labeyrie, Lariboisière -Paris

O. Naggara, D. Trystram, C. Rodriguez-regent, B. Hassen, W. Boulouis et al.,

M. Piotin, H. Redjem, and R. Blanc,

C. J. Spellel, G. Saliou, A. Rouchaud, L. Ikka, and J. Moret,

, Gentric JC (University Hospital of Brest

V. Costalat, C. Darganzil, and O. Ecker, University Hospital of Montpellier

A. Kazemi, L. Lestrade, and X. Leclerc,

M. Musacchio and P. Lebedinsky, Hospital of Colmar

M. Garnier-viarouge, Hospital of LaRoche Sur Yon

, Lévrier O (Hospital of Clairval

, Aggour M (University Hospital of saint Etienne

, REFERENCES

M. Vlak, A. Algra, R. Brandenburg, and G. Rinkel, Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis, The Lancet Neurology, vol.10, issue.7, pp.626-636, 2011.
DOI : 10.1016/S1474-4422(11)70109-0

E. Laaksamo, M. Ramachandran, and J. Frösen, Intracellular Signaling Pathways and Size, Shape, and Rupture History of Human Intracranial Aneurysms, Neurosurgery, vol.20, issue.4, pp.121565-1572
DOI : 10.3171/jns.1963.20.4.0329

D. Nieuwkamp, L. Setz, A. Algra, F. Linn, D. Rooij et al., Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis, The Lancet Neurology, vol.8, issue.7, pp.635-642, 2009.
DOI : 10.1016/S1474-4422(09)70126-7

L. Pierot, L. Spelle, and F. Vitry, Immediate Clinical Outcome of Patients Harboring Unruptured Intracranial Aneurysms Treated by Endovascular Approach: Results of the ATENA Study, Stroke, vol.39, issue.9, pp.2497-2504, 2008.
DOI : 10.1161/STROKEAHA.107.512756
URL : https://hal.archives-ouvertes.fr/hal-00741687

T. Huttunen, M. Von-und-zufraunberg, and J. Frösen, Saccular Intracranial Aneurysm Disease, Neurosurgery, vol.103, issue.8, pp.631-638, 2010.
DOI : 10.1161/CIRCRESAHA.108.181818

S. Bacigaluppi, M. Piccinelli, and L. Antiga, Factors affecting formation and rupture of intracranial saccular aneurysms, Neurosurgical Review, vol.35, issue.9, pp.1-14, 2014.
DOI : 10.1016/S1357-2725(03)00043-8

J. Frösen, Smooth Muscle Cells and the Formation, Degeneration, and Rupture of Saccular Intracranial Aneurysm Wall???a Review of Current Pathophysiological Knowledge, Translational Stroke Research, vol.66, issue.3, pp.347-356, 2014.
DOI : 10.1227/01.NEU.0000365616.46414.2B

M. Vlak, G. Rinkel, P. Greebe, and A. Algra, Independent Risk Factors for Intracranial Aneurysms and Their Joint Effect: A Case-Control Study, Stroke, vol.44, issue.4, pp.984-987, 2013.
DOI : 10.1161/STROKEAHA.111.000329
URL : http://stroke.ahajournals.org/content/strokeaha/44/4/984.full.pdf

R. Bourcier, R. Redon, and H. Desal, Genetic investigations on intracranial aneurysm: Update and perspectives, Journal of Neuroradiology, vol.42, issue.2, pp.67-71, 2015.
DOI : 10.1016/j.neurad.2015.01.002
URL : https://hal.archives-ouvertes.fr/hal-01830979

V. Alg, R. Sofat, H. Houlden, and D. Werring, Genetic risk factors for intracranial aneurysms: A meta-analysis in more than 116,000 individuals, Neurology, vol.80, issue.23, pp.2154-2165, 2013.
DOI : 10.1212/WNL.0b013e318295d751
URL : http://www.neurology.org/content/80/23/2154.full.pdf

K. Yasuno, M. Bak?rc?o?lu, and S. Low, Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk, Proc. Natl. Acad. Sci
DOI : 10.1371/journal.pgen.1000540
URL : http://www.pnas.org/content/108/49/19707.full.pdf

U. S. , , 2011.

J. Huston, D. Nichols, and P. Luetmer, Blinded prospective evaluation of sensitivity of MR angiography to known intracranial aneurysms: importance of aneurysm size, AJNR Am J Neuroradiol, vol.15, pp.1607-1614, 1994.

Y. Korogi, M. Takahashi, and N. Mabuchi, Intracranial aneurysms: diagnostic accuracy of three-dimensional, Fourier transform, time-of-flight MR angiography., Radiology, vol.193, issue.1, pp.181-186, 1994.
DOI : 10.1148/radiology.193.1.8090889

D. Wilcock, T. Jaspan, I. Holland, G. Cherryman, and B. Worthington, Comparison of magnetic resonance angiography with conventional angiography in the detection of intracranial aneurysms in patients presenting with subarachnoid haemorrhage, Clinical Radiology, vol.51, issue.5, pp.330-334, 1996.
DOI : 10.1016/S0009-9260(96)80109-7

P. Maeder, R. Meuli, D. Tribolet, and N. , Three-dimensional volume rendering for magnetic resonance angiography in the screening and preoperative workup of intracranial aneurysms, Journal of Neurosurgery, vol.15, issue.6
DOI : 10.1161/01.STR.23.10.1416

, J Neurosurg. déc, vol.85, pp.1050-1055, 1996.

M. Harrison, B. Johnson, G. Gardner, and B. Welling, Preliminary Results on the Management of Unruptured Intracranial Aneurysms with Magnetic Resonance Angiography and Computed Tomographic Angiography, Neurosurgery, vol.66, issue.5, pp.947-55, 1997.
DOI : 10.3171/jns.1987.66.1.0023

C. Grandin, P. Mathurin, and T. Duprez, Diagnosis of intracranial aneurysms: accuracy of MR angiography at 0.5 T, AJNR Am J Neuroradiol, vol.19, pp.245-252, 1998.

H. Cloft, D. Kallmes, M. Kallmes, J. Goldstein, M. Jensen et al., Prevalence of cerebral aneurysms in patients with fibromuscular dysplasia: a reassessment, Journal of Neurosurgery, vol.151, issue.3, pp.436-440, 1998.
DOI : 10.1016/0002-9610(86)90100-5

B. Brown and F. Soldevilla, MR angiography and surgery for unruptured familial intracranial aneurysms in persons with a family history of cerebral aneurysms., American Journal of Roentgenology, vol.173, issue.1, pp.133-138, 1999.
DOI : 10.2214/ajr.173.1.10397113

Y. Korogi, M. Takahashi, and N. Mabuchi, Intracranial aneurysms: diagnostic accuracy of MR angiography with evaluation of maximum intensity projection and source images., Radiology, vol.199, issue.1, pp.156-162, 1996.
DOI : 10.1148/radiology.199.1.8633146

F. Fazekas, A. Alavi, and J. Chawluk, Comparison of CT, MR, and PET in Alzheimer's dementia and normal aging, J. Nucl. Med, vol.30, pp.1607-1615, 1989.

, FIGURE LEGEND

, Figure 1: Pedigree of a 3 generation family with 6 patients affected by IA. Arrows indicate probands. Asterisks indicate exome-sequenced individuals