The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis

Katharina Weinhäupl (1) , Martha Brennich (2) , Uli Kazmaier , Joël Lelièvre (3) , Lluis Ballell (4) , Alfred Goldberg , Paul Schanda (1) , Hugo Fraga (1)

1 IBS - UMR 5075 - Institut de biologie structurale
2 ESRF - European Synchrotron Radiation Facility
3 LCC - Laboratoire de chimie de coordination
4 DDW - Diseases of the Developing World [Tres Cantos, Madrid]

Mots clés: nuclear magnetic resonance; Mycobacterium tuberculosis; natural product; antibiotic action; antibiotic resistance; small angle X-ray scattering; protease; chaperone

Domaines: Biologie structurale [q-bio.BM]

Katharina Weinhäupl, Martha Brennich, Uli Kazmaier, Joël Lelièvre, Lluis Ballell, et al.. The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis. Journal of Biological Chemistry, 2018, ⟨10.1074/jbc.RA118.002251⟩. ⟨hal-01768184⟩