M. Abbracchio, G. Burnstock, A. Verkhratsky, and H. Zimmermann, Purinergic signalling in the nervous system: an overview, Trends in Neurosciences, vol.32, issue.1, pp.19-29, 2009.
DOI : 10.1016/j.tins.2008.10.001

J. Arbeloa, A. Perez-samartin, M. Gottlieb, and C. Matute, P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia, Neurobiology of Disease, vol.45, issue.3, pp.954-961, 2012.
DOI : 10.1016/j.nbd.2011.12.014

K. Baalman, R. Cotton, S. Rasband, and M. Rasband, Blast Wave Exposure Impairs Memory and Decreases Axon Initial Segment Length, Journal of Neurotrauma, vol.30, issue.9, pp.741-751, 2013.
DOI : 10.1089/neu.2012.2478

URL : http://europepmc.org/articles/pmc3941920?pdf=render

K. Bender and L. Trussell, The Physiology of the Axon Initial Segment, Annual Review of Neuroscience, vol.35, issue.1, pp.249-265, 2012.
DOI : 10.1146/annurev-neuro-062111-150339

M. Brater, S. Li, I. Gorodezkaya, A. K. Ravens, and U. , Voltage-sensitive Ca2+ channels, intracellular Ca2+ stores and Ca2+-release-activated Ca2+ channels contribute to the ATP-induced [Ca2+]i increase in differentiated neuroblastoma??glioma NG 108-15 cells, Neuroscience Letters, vol.264, issue.1-3, pp.97-100, 1999.
DOI : 10.1016/S0304-3940(99)00189-5

A. Brechet, M. Fache, A. Brachet, G. Ferracci, A. Baude et al., Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G, The Journal of Cell Biology, vol.267, issue.6, pp.1101-1114, 2008.
DOI : 10.1083/jcb.143.5.1295

URL : https://hal.archives-ouvertes.fr/hal-01701558

S. Buffington and M. Rasband, The axon initial segment in nervous system disease and injury, European Journal of Neuroscience, vol.69, issue.10, pp.1609-1619, 2011.
DOI : 10.1016/j.neuron.2011.02.021

C. Cario-toumaniantz, G. Loirand, L. Ferrier, and P. Pacaud, purinoceptor by 17??-oestradiol, The Journal of Physiology, vol.1, issue.3, pp.659-666, 1998.
DOI : 10.1146/annurev.physiol.59.1.365

F. Cavaliere, S. Amadio, G. Sancesario, G. Bernardi, and C. Volonte, and Oxygen/Glucose Deprivation in Organotypic Hippocampal Cultures, Journal of Cerebral Blood Flow & Metabolism, vol.52, issue.4, pp.392-398, 2004.
DOI : 10.1016/0165-0270(91)90128-M

D. Cruz, C. Weaver, E. Lovallo, D. Melchitzky, and D. Lewis, Selective Alterations in Postsynaptic Markers of Chandelier Cell Inputs to Cortical Pyramidal Neurons in Subjects with Schizophrenia, Neuropsychopharmacology, vol.156, issue.9, pp.2112-2124, 2009.
DOI : 10.1083/jcb.143.5.1295

D. Debanne, S. Boudkkazi, E. Campanac, R. Cudmore, P. Giraud et al., Paired-recordings from synaptically coupled cortical and hippocampal neurons in acute and cultured brain slices, Nature Protocols, vol.23, issue.10, pp.1559-1568, 2008.
DOI : 10.1113/jphysiol.1996.sp021204

URL : https://hal.archives-ouvertes.fr/inserm-00484944

A. Del-puerto, J. Diaz-hernandez, M. Tapia, R. Gomez-villafuertes, M. Benitez et al., Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation, Journal of Cell Science, vol.125, issue.1, pp.176-188, 2012.
DOI : 10.1242/jcs.091736

J. Diaz-hernandez, R. Gomez-villafuertes, M. Leon-otegui, L. Hontecillas-prieto, D. Puerto et al., In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3?? and secretases, Neurobiology of Aging, vol.33, issue.8, pp.1816-1828, 2012.
DOI : 10.1016/j.neurobiolaging.2011.09.040

M. Diaz-hernandez, A. Del-puerto, J. Diaz-hernandez, M. Diez-zaera, J. Lucas et al., Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons, Journal of Cell Science, vol.121, issue.22, pp.3717-3728, 2008.
DOI : 10.1242/jcs.034082

M. Diaz-hernandez, M. Diez-zaera, J. Sanchez-nogueiro, R. Gomez-villafuertes, J. Canals et al., Altered P2X7-receptor level and function in mouse models of Huntington???s disease and therapeutic efficacy of antagonist administration, The FASEB Journal, vol.23, issue.6, pp.1893-1906, 2009.
DOI : 10.1001/archopht.124.4.514

M. Ehrengruber, S. Hennou, H. Bueler, H. Naim, N. Deglon et al., Gene Transfer into Neurons from Hippocampal Slices: Comparison of Recombinant Semliki Forest Virus, Adenovirus, Adeno-Associated Virus, Lentivirus, and Measles Virus, Molecular and Cellular Neuroscience, vol.17, issue.5, pp.855-871, 2001.
DOI : 10.1006/mcne.2001.0982

M. Evans, R. Sammons, S. Lebron, A. Dumitrescu, T. Watkins et al., Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment, Journal of Neuroscience, vol.33, issue.16, pp.6950-6963, 2013.
DOI : 10.1523/JNEUROSCI.0277-13.2013

H. Franke, A. Gunther, J. Grosche, R. Schmidt, S. Rossner et al., Receptor Expression after Ischemia in the Cerebral Cortex of Rats, Journal of Neuropathology & Experimental Neurology, vol.280, issue.7, pp.686-699, 2004.
DOI : 10.1002/cne.10608

S. Friedle, M. Curet, and J. Watters, Recent Patents on Novel P2X7 Receptor Antagonists and their Potential for Reducing Central Nervous System Inflammation, Recent Patents on CNS Drug Discovery, vol.5, issue.1, pp.35-45, 2010.
DOI : 10.2174/157488910789753530

J. Garrido, P. Giraud, E. Carlier, F. Fernandes, A. Moussif et al., A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment, Science, vol.300, issue.5628, pp.2091-2094, 2003.
DOI : 10.1126/science.1085167

M. Grubb and J. Burrone, Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability, Nature, vol.9, issue.7301, pp.1070-1074, 2010.
DOI : 10.1113/jphysiol.1995.sp020862

Y. Gutierrez-martin, D. Bustillo, R. Gomez-villafuertes, J. Sanchez-nogueiro, C. Torregrosa-hetland et al., P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells, Journal of Biological Chemistry, vol.20, issue.13, pp.11370-11381, 2011.
DOI : 10.1016/0014-5793(96)00732-6

K. Hedstrom, Y. Ogawa, and M. Rasband, AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity, The Journal of Cell Biology, vol.120, issue.4, pp.635-640, 2008.
DOI : 10.1038/ncb1603

J. Hinman, M. Rasband, and S. Carmichael, Remodeling of the Axon Initial Segment After Focal Cortical and White Matter Stroke, Stroke, vol.44, issue.1, pp.182-189, 2013.
DOI : 10.1161/STROKEAHA.112.668749

S. Hwang, J. Li, N. Koo, S. Choi, S. Lee et al., Role of Purinergic Receptor in Alpha Fodrin Degradation in Par C5 Cells, Journal of Dental Research, vol.88, issue.10, pp.927-932, 2009.
DOI : 10.1167/iovs.05-0052

L. Jiang, J. Baldwin, S. Roger, and S. Baldwin, Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms, Frontiers in Pharmacology, vol.4, p.55, 2013.
DOI : 10.3389/fphar.2013.00055

L. Jiang, A. Mackenzie, R. North, and A. Surprenant, Receptors, Molecular Pharmacology, vol.58, issue.1, pp.82-88, 2000.
DOI : 10.1124/mol.58.1.82

URL : https://hal.archives-ouvertes.fr/hal-01498063

S. Jo and B. Bean, Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G, Molecular Pharmacology, vol.80, issue.2, pp.247-257, 2011.
DOI : 10.1124/mol.110.070276

S. Kaech and G. Banker, Culturing hippocampal neurons, Nature Protocols, vol.31, issue.5, pp.2406-2415, 2006.
DOI : 10.1016/0378-1119(91)90434-D

A. Kampfl, R. Posmantur, R. Nixon, F. Grynspan, X. Zhao et al., ??-Calpain Activation and Calpain-Mediated Cytoskeletal Proteolysis Following Traumatic Brain Injury, Journal of Neurochemistry, vol.67, issue.4, pp.1575-1583, 1996.
DOI : 10.1046/j.1471-4159.1996.67041575.x

H. Kaphzan, S. Buffington, J. Jung, M. Rasband, and E. Klann, Alterations in Intrinsic Membrane Properties and the Axon Initial Segment in a Mouse Model of Angelman Syndrome, Journal of Neuroscience, vol.31, issue.48, pp.17637-17648, 2011.
DOI : 10.1523/JNEUROSCI.4162-11.2011

J. Kim, S. Kwak, S. Jo, and T. Kang, Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus, Neurological Research, vol.31, issue.9, pp.982-988, 2009.
DOI : 10.1016/j.brainres.2006.08.057

D. Kimbler, J. Shields, N. Yanasak, J. Vender, and K. Dhandapani, Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice, PLoS ONE, vol.94, issue.7, p.41229, 2012.
DOI : 10.1371/journal.pone.0041229.g008

M. Kole, S. Ilschner, B. Kampa, S. Williams, P. Ruben et al., Action potential generation requires a high sodium channel density in the axon initial segment, Nature Neuroscience, vol.26, issue.2, pp.178-186, 2008.
DOI : 10.1113/jphysiol.1982.sp014296

H. Kuba, Y. Oichi, and H. Ohmori, Presynaptic activity regulates Na+ channel distribution at the axon initial segment, Nature, vol.277, issue.7301, pp.1075-1078, 2010.
DOI : 10.1038/nature09087

E. Longa, P. Weinstein, S. Carlson, and R. Cummins, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, vol.20, issue.1, pp.84-91, 1989.
DOI : 10.1161/01.STR.20.1.84

C. Matute, T. I. Perez-cerda, F. Perez-samartin, A. Alberdi, E. Etxebarria et al., P2X7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis, Journal of Neuroscience, vol.27, issue.35, pp.9525-9533, 2007.
DOI : 10.1523/JNEUROSCI.0579-07.2007

A. Melani, F. Corti, H. Stephan, C. Muller, C. Donati et al., Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum, Experimental Neurology, vol.233, issue.1, pp.193-204, 2012.
DOI : 10.1016/j.expneurol.2011.09.036

A. Melani, D. Turchi, M. Vannucchi, S. Cipriani, M. Gianfriddo et al., ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia, Neurochemistry International, vol.47, issue.6, pp.442-448, 2005.
DOI : 10.1016/j.neuint.2005.05.014

K. Nishida, T. Nakatani, A. Ohishi, H. Okuda, Y. Higashi et al., Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death, Journal of Neurochemistry, vol.48, issue.Pt 2, pp.1118-1128, 2012.
DOI : 10.1016/j.fct.2010.01.001

R. North and A. Surprenant, Pharmacology of Cloned P2X Receptors, Annual Review of Pharmacology and Toxicology, vol.40, issue.1, pp.563-580, 2000.
DOI : 10.1146/annurev.pharmtox.40.1.563

Y. Ogawa, I. Horresh, J. Trimmer, D. Bredt, E. Peles et al., Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2, Journal of Neuroscience, vol.28, issue.22, pp.5731-5739, 2008.
DOI : 10.1523/JNEUROSCI.4431-07.2008

Z. Pan, T. Kao, Z. Horvath, J. Lemos, J. Sul et al., A Common Ankyrin-G-Based Mechanism Retains KCNQ and NaV Channels at Electrically Active Domains of the Axon, Journal of Neuroscience, vol.26, issue.10, pp.2599-2613, 2006.
DOI : 10.1523/JNEUROSCI.4314-05.2006

L. Parvathenani, S. Tertyshnikova, C. Greco, S. Roberts, B. Robertson et al., Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease, Journal of Biological Chemistry, vol.92, issue.15, pp.13309-13317, 2003.
DOI : 10.1002/jlb.64.2.265

M. Perez-alvarez, M. Mdel, C. , A. M. Ordonez, L. Wandosell et al., Post-ischemic estradiol treatment reduced glial response and triggers distinct cortical and hippocampal signaling in a rat model of cerebral ischemia, Journal of Neuroinflammation, vol.20, issue.1-2, p.157, 2012.
DOI : 10.1093/emboj/20.1.27

S. Ray, E. Hogan, and N. Banik, Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors, Brain Research Reviews, vol.42, issue.2, pp.169-185, 2003.
DOI : 10.1016/S0165-0173(03)00152-8

D. Sanchez-ponce, A. Munoz, and J. Garrido, Casein kinase 2 and microtubules control axon initial segment formation, Molecular and Cellular Neuroscience, vol.46, issue.1, pp.222-234, 2011.
DOI : 10.1016/j.mcn.2010.09.005

D. Schafer, S. Jha, F. Liu, T. Akella, L. Mccullough et al., Disruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal Injury, Journal of Neuroscience, vol.29, issue.42, pp.13242-13254, 2009.
DOI : 10.1523/JNEUROSCI.3376-09.2009

M. Tapia, D. Puerto, A. Puime, A. Sanchez-ponce, D. Fronzaroli-molinieres et al., GSK3 and ??-catenin determines functional expression of sodium channels at the axon initial segment, Cellular and Molecular Life Sciences, vol.30, issue.21, pp.105-120, 2013.
DOI : 10.1016/j.tins.2007.02.002

H. Vacher, J. Yang, O. Cerda, A. Autillo-touati, B. Dargent et al., Cdk-mediated phosphorylation of the Kv??2 auxiliary subunit regulates Kv1 channel axonal targeting, The Journal of Cell Biology, vol.19, issue.5, pp.813-824, 2011.
DOI : 10.1073/pnas.95.4.1846

URL : https://hal.archives-ouvertes.fr/hal-00751800

E. Vianna, A. Ferreira, M. Naffah-mazzacoratti, E. Sanabria, M. Funke et al., Evidence That ATP Participates in the Pathophysiology of Pilocarpine-Induced Temporal Lobe Epilepsy: A Fluorimetric, Immunohistochemical, and Western Blot Studies, Epilepsia, vol.16, pp.227-229, 2002.
DOI : 10.1097/00001756-199604100-00015

C. Von-reyn, J. Spaethling, M. Mesfin, M. Ma, R. Neumar et al., Calpain Mediates Proteolysis of the Voltage-Gated Sodium Channel ??-Subunit, Journal of Neuroscience, vol.29, issue.33, pp.10350-10356, 2009.
DOI : 10.1523/JNEUROSCI.2339-09.2009

P. Vosler, C. Brennan, and J. Chen, Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration, Molecular Neurobiology, vol.9, issue.Suppl 2, pp.78-100, 2008.
DOI : 10.1042/bj2210813

X. Wang, G. Arcuino, T. Takano, J. Lin, W. Peng et al., P2X7 receptor inhibition improves recovery after spinal cord injury, Nature Medicine, vol.22, issue.8, pp.821-827, 2004.
DOI : 10.1038/nbt944

K. Wirkner, A. Kofalvi, W. Fischer, A. Gunther, H. Franke et al., Supersensitivity of P2X7 receptors in cerebrocortical cell cultures after in???vitro ischemia, Journal of Neurochemistry, vol.10, issue.5, pp.1421-1437, 2005.
DOI : 10.1152/physrev.00015.2002

J. Yrjanheikki, J. Koistinaho, M. Kettunen, R. Kauppinen, K. Appel et al., Long-term protective effect of atorvastatin in permanent focal cerebral ischemia, Brain Research, vol.1052, issue.2, pp.174-179, 2005.
DOI : 10.1016/j.brainres.2005.06.004

M. Zhang, W. Li, G. Niu, R. Leak, C. J. Zhang et al., ATP Induces Mild Hypothermia in Rats but has a Strikingly Detrimental Impact on Focal Cerebral Ischemia, Journal of Cerebral Blood Flow & Metabolism, vol.3, issue.3, pp.1-10, 2013.
DOI : 10.1038/sj.bjp.0705685

W. Zheng, L. Watts, D. Holstein, S. Prajapati, C. Keller et al., Purinergic Receptor Stimulation Reduces Cytotoxic Edema and Brain Infarcts in Mouse Induced by Photothrombosis by Energizing Glial Mitochondria, PLoS ONE, vol.158, issue.12, p.14401, 2010.
DOI : 10.1371/journal.pone.0014401.s010