Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications

Abstract : A challenge regarding the design of nanocarriers for drug delivery is to prevent their recognition by the immune system. To improve the blood residence time and prevent their capture by organs, nanoparticles can be designed with stealth properties using polymeric coating. In this study, we focused on the influence of surface modification with polyethylene glycol and/or mannose on the stealth behavior of porous silicon nanoparticles (pSiNP, similar to 200 nm). In vivo biodistribution of pSiNPs formulations were evaluated in mice 5 h after intravenous injection. Results indicated that the distribution in the organs was surface functionalization-dependent. Pristine pSiNPs and PEGylated pSiNPs were distributed mainly in the liver and spleen, while mannose-functionalized pSiNPs escaped capture by the spleen, and had higher blood retention. The most efficient stealth behavior was observed with PEGylated pSiNPs anchored with mannose that were the most excreted in urine at 5 h. The biodegradation kinetics evaluated in vitro were in agreement with these in vivo observations. The biocompatibility of the pristine and functionalized pSiNPs was confirmed in vitro on human cell lines and in vivo by cytotoxic and systemic inflammation investigations, respectively. With their biocompatibility, biodegradability, and stealth properties, the pSiNPs functionalized with mannose and PEG show promising potential for biomedical applications.
Type de document :
Article dans une revue
Nanomaterials, Multidisciplinary Digital Publishing Institute (MDPI), 2017, 7 (10), pp.288. 〈10.3390/nano7100288〉
Liste complète des métadonnées

Littérature citée [44 références]  Voir  Masquer  Télécharger

https://hal.archives-ouvertes.fr/hal-01765618
Contributeur : Catherine Beaussier <>
Soumis le : vendredi 13 avril 2018 - 18:50:42
Dernière modification le : mardi 29 mai 2018 - 12:51:02

Fichier

nanomaterials-07-00288.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Wei Liu, Arnaud Chaix, Magali Gary-Bobo, Bernard Angeletti, Armand Masion, et al.. Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications. Nanomaterials, Multidisciplinary Digital Publishing Institute (MDPI), 2017, 7 (10), pp.288. 〈10.3390/nano7100288〉. 〈hal-01765618〉

Partager

Métriques

Consultations de la notice

438

Téléchargements de fichiers

46