MicroRNA expression profiling of hypothalamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology, Journal of Neuroscience Methods, vol.209, issue.1, pp.134-143, 2012. ,
DOI : 10.1016/j.jneumeth.2012.05.033
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training, Nature Neuroscience, vol.6, issue.3, pp.351-355, 2011. ,
DOI : 10.1002/ar.1090940210
Probing microRNAs with microarrays: Tissue specificity and functional inference, RNA, vol.10, issue.11, pp.1813-1819, 2004. ,
DOI : 10.1261/rna.7119904
MicroRNA expression in the adult mouse central nervous system, RNA, vol.14, issue.3, pp.432-444, 2008. ,
DOI : 10.1261/rna.783108
Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis, Neuron, vol.42, issue.6, pp.983-991, 2004. ,
DOI : 10.1016/j.neuron.2004.06.004
An Update in the Management of Obesity: The Weight of CNS Targets, Recent Patents on CNS Drug Discovery, vol.6, issue.3, pp.164-180, 2011. ,
DOI : 10.2174/157488911796958048
MicroRNAs, Cell, vol.116, issue.2, pp.281-297, 2004. ,
DOI : 10.1016/S0092-8674(04)00045-5
URL : https://hal.archives-ouvertes.fr/hal-00369966
Early leptin blockade predisposes fat-fed rats to overweight and modifies hypothalamic microRNAs, Journal of Endocrinology, vol.20, issue.8, pp.35-47, 2013. ,
DOI : 10.1007/s00335-009-9217-2
URL : https://hal.archives-ouvertes.fr/hal-01179309
Multiple neural systems controlling food intake and body weight, Neuroscience & Biobehavioral Reviews, vol.26, issue.4, pp.393-428, 2002. ,
DOI : 10.1016/S0149-7634(02)00014-3
The caudal brainstem and the control of food intake and energy balance, " in Neurobiology of Food and Fluid Intake Handbook of Behavioral Neurobiology Available online at, pp.195-2400, 1007. ,
Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding, Science, vol.304, issue.5667, pp.108-110, 2004. ,
DOI : 10.1126/science.1095004
Hypothalamic regulation of energy balance: a key role for DICER miRNA processing in arcuate POMC neurons, Molecular Metabolism, vol.2, issue.2, pp.55-57, 2012. ,
DOI : 10.1016/j.molmet.2012.12.001
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons, Journal of Clinical Investigation, vol.117, issue.8, pp.2325-2336, 1172. ,
DOI : 10.1172/JCI31516DS1
Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.6, pp.2557-25622004, 2004. ,
DOI : 10.1210/jc.2004-0428
URL : https://academic.oup.com/jcem/article-pdf/89/6/2557/10742481/jcem2557.pdf
The hypothalamic arcuate nucleus: A key site for mediating leptin???s effects on glucose homeostasis and locomotor activity, Cell Metabolism, vol.1, issue.1, pp.63-72004, 2004. ,
DOI : 10.1016/j.cmet.2004.12.004
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus, Nature, vol.411, issue.6836, pp.480-484, 1038. ,
DOI : 10.1038/35078085
The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment, Molecular and Cellular Endocrinology, vol.384, issue.1-2, pp.1-11, 2014. ,
DOI : 10.1016/j.mce.2013.12.016
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration, Proceedings of the National Academy of Sciences, vol.12, issue.2, pp.5614-5619, 2008. ,
DOI : 10.1261/rna.2258506
Melanocortins and body weight: a tale of two receptors, Nature Genetics, vol.26, issue.1, pp.8-9, 2000. ,
DOI : 10.1038/79223
Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3'UTR. Front, Cell. Neurosci, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01212345
An Emerging Role of micro-RNA in the Effect of the Endocrine Disruptors, Frontiers in Neuroscience, vol.64, issue.3, 2016. ,
DOI : 10.1016/j.jpsychires.2015.02.018
URL : https://hal.archives-ouvertes.fr/hal-01471933
Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis, Neuron, vol.49, issue.2, pp.191-203021, 2005. ,
DOI : 10.1016/j.neuron.2005.12.021
Abstract, Reviews in the Neurosciences, vol.0, issue.0, pp.675-686, 2014. ,
DOI : 10.1515/revneuro-2014-0014
Specificity of microRNA target selection in translational repression, Genes & Development, vol.18, issue.5, pp.504-511, 2004. ,
DOI : 10.1101/gad.1184404
Substantial and robust changes in microRNA transcriptome support postnatal development of the hypothalamus in rat The widespread impact of mammalian MicroRNAs on mRNA repression and evolution, Science, vol.310, pp.1817-1821, 2005. ,
Recent advances: Recent advances in the genetics of severe childhood obesity, Archives of Disease in Childhood, vol.83, issue.1, pp.31-34, 2000. ,
DOI : 10.1136/adc.83.1.31
Most mammalian mRNAs are conserved targets of microRNAs, Genome Research, vol.19, issue.1, pp.92-105, 2009. ,
DOI : 10.1101/gr.082701.108
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs, Proceedings of the National Academy of Sciences, vol.107, issue.26, pp.21075-21080, 2011. ,
DOI : 10.1073/pnas.1007158107
Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus, PLoS ONE, vol.149, issue.4, 2011. ,
DOI : 10.1371/journal.pone.0018950.g006
Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior, Molecular Endocrinology, vol.27, issue.7, pp.1091-11022012, 2013. ,
DOI : 10.1210/me.2012-1344
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing, Molecular Cell, vol.27, issue.1, pp.91-105, 2007. ,
DOI : 10.1016/j.molcel.2007.06.017
Mammalian microRNAs predominantly act to decrease target mRNA levels, Nature, vol.5, issue.7308, pp.835-840, 2010. ,
DOI : 10.1038/nature09267
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, Human Molecular Genetics, vol.24, issue.20, 2010. ,
DOI : 10.1523/JNEUROSCI.5561-03.2004
Locked nucleic acidbased in situ hybridization reveals mir-7a as a hypothalamus-enriched microRNA with a distinct expression pattern, J. Neuroendocrinol, 2012. ,
Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility, Cell Metabolism, vol.11, issue.4, pp.286-297, 2010. ,
DOI : 10.1016/j.cmet.2010.03.002
The YY3-36 peptide, a new therapeutic weapon against obesity, Med. Sci, vol.19, pp.537-539, 2003. ,
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells, Cell Metabolism, vol.4, issue.2, pp.123-132, 2006. ,
DOI : 10.1016/j.cmet.2006.06.010
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans, Nature Genetics, vol.86, issue.2, pp.155-157, 1038. ,
DOI : 10.1073/pnas.86.8.2766
MicroRNAs: A new class of regulatory genes affecting metabolism, Cell Metabolism, vol.4, issue.1, 2006. ,
DOI : 10.1016/j.cmet.2006.05.009
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors, RNA, vol.14, issue.1, pp.35-42, 2008. ,
DOI : 10.1261/rna.804508
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 The role of leptin-melanocortin system and human weight regulation: lessons from experiments of nature, Cell Ann. Acad. Med. Singap, vol.75, issue.38, pp.843-854, 1993. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00597159
Embryonic development of the hypothalamic feeding circuitry: Transcriptional, nutritional, and hormonal influences, Molecular Metabolism, vol.3, issue.9, 2014. ,
DOI : 10.1016/j.molmet.2014.09.004
A Neuron-Specific Deletion of the MicroRNA-Processing Enzyme DICER Induces Severe but Transient Obesity in Mice, PLOS ONE, vol.34, issue.1, 2015. ,
DOI : 10.1371/journal.pone.0116760.s006
Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model, Gene, vol.497, issue.2, pp.181-190, 2012. ,
DOI : 10.1016/j.gene.2012.01.057
Leptin action in the forebrain regulates the hindbrain response to satiety signals, Journal of Clinical Investigation, vol.115, issue.3, pp.703-710, 1172. ,
DOI : 10.1172/JCI200522081
Central nervous system control of food intake and body weight, Nature, vol.81, issue.7109, pp.289-295, 1038. ,
DOI : 10.1016/j.physbeh.2004.04.034
Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System, Neuropsychopharmacology, vol.52, issue.2, pp.424-43573, 2008. ,
DOI : 10.1038/12506
URL : https://hal.archives-ouvertes.fr/inserm-00349463
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons, The FASEB Journal, vol.24, issue.6, pp.1747-1758, 2010. ,
DOI : 10.1210/en.2002-220659
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein, Science, vol.268, issue.5335, pp.135-138, 1997. ,
DOI : 10.1093/hmg/4.2.223
MicroRNAs Show Mutually Exclusive Expression Patterns in the Brain of Adult Male Rats, PLoS ONE, vol.19, issue.490, 2009. ,
DOI : 10.1371/journal.pone.0007225.s002
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity, Nature Cell Metab, vol.449, issue.12, pp.228-232, 2007. ,
Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis, Cell Metabolism, vol.13, issue.2, pp.195-204, 2011. ,
DOI : 10.1016/j.cmet.2011.01.010
Perturbation of Hypothalamic MicroRNA Expression Patterns in Male Rats After Metabolic Distress: Impact of Obesity and Conditions of Negative Energy Balance, Endocrinology, vol.155, issue.5, pp.1838-1850, 2014. ,
DOI : 10.1210/en.2013-1770
Cerebellar neurodegeneration in the absence of microRNAs, The Journal of Experimental Medicine, vol.312, issue.7, pp.1553-1558, 2007. ,
DOI : 10.1073/pnas.96.25.14588
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity, Molecular Metabolism, vol.2, issue.2, pp.74-85, 2012. ,
DOI : 10.1016/j.molmet.2012.10.001
Hypothalamic miRNAs: emerging roles in energy balance control, Frontiers in Neuroscience, vol.3, issue.175, 2015. ,
DOI : 10.1371/journal.pbio.0030415
Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance, Journal of Endocrinology, vol.298, issue.3, pp.25-46, 2014. ,
DOI : 10.1152/ajpregu.00619.2009
URL : http://joe.endocrinology-journals.org/content/220/2/T25.full.pdf
Widespread changes in protein synthesis induced by microRNAs Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition, Nature Endocrinology, vol.455, issue.151, pp.58-63, 1210. ,
Epigenetic changes in the hypothalamic pro-opiomelanocortin gene: A mechanism linking maternal undernutrition to obesity in the offspring?, European Journal of Pharmacology, vol.660, issue.1, pp.194-201, 2011. ,
DOI : 10.1016/j.ejphar.2010.10.111
Deletion of Astroglial Dicer Causes Non-Cell-Autonomous Neuronal Dysfunction and Degeneration, Journal of Neuroscience, vol.31, issue.22, pp.8306-8319, 2011. ,
DOI : 10.1523/JNEUROSCI.0567-11.2011
Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion, Endocrinology, vol.149, issue.4, pp.1773-17852007, 2008. ,
DOI : 10.1210/en.2007-1132
Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice, Journal of Neuroscience, vol.34, issue.32, pp.10659-10674, 2014. ,
DOI : 10.1523/JNEUROSCI.4251-13.2014