Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

Abstract : Enzymes belonging to mechanistically diverse superfamilies often display similar catalytic mechanisms. We previously observed such an association in the case of the cyclic amidohydrolase superfamily whose members play a role in related steps of purine and pyrimidine metabolic pathways. To establish a possible link between enzyme homology and chemical similarity, we investigated further the neighbouring steps in the respective pathways.
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Matthieu Barba, Raphaël Dutoit, Christianne Legrain, Bernard Labedan. Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism. BMC Systems Biology, BioMed Central, 2013, 7, pp.99. ⟨10.1186/1752-0509-7-99⟩. ⟨hal-01758866⟩

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