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Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

Matthieu Barba 1, 2 Raphaël Dutoit 3 Christianne Legrain 3 Bernard Labedan 1, 4, *
* Corresponding author
1 IGM - Institut de génétique et microbiologie [Orsay]
2 BPGE - Bioinformatique, phylogénie et génomique évolutive
PEGASE - Département PEGASE [LBBE]
3 Laboratoire de Microbiologie, Université Libre de Bruxelles Institut de Recherches Microbiologiques J.-M. Wiame
4 BioInfo - LRI - Bioinformatique (LRI)
LRI - Laboratoire de Recherche en Informatique
Abstract : Enzymes belonging to mechanistically diverse superfamilies often display similar catalytic mechanisms. We previously observed such an association in the case of the cyclic amidohydrolase superfamily whose members play a role in related steps of purine and pyrimidine metabolic pathways. To establish a possible link between enzyme homology and chemical similarity, we investigated further the neighbouring steps in the respective pathways.
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https://hal.archives-ouvertes.fr/hal-01758866
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Submitted on : Wednesday, April 4, 2018 - 6:44:09 PM
Last modification on : Tuesday, April 21, 2020 - 1:06:46 AM

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Matthieu Barba, Raphaël Dutoit, Christianne Legrain, Bernard Labedan. Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism. BMC Systems Biology, BioMed Central, 2013, 7, pp.99. ⟨10.1186/1752-0509-7-99⟩. ⟨hal-01758866⟩

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