Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls

Sarah Marouen (1) , Guilhem Du Cailar (1) , Rachel Audo (1) , Cedric Lukas (1) , Gaëlle Vial (2) , Anne Tournadre (3) , Emmanuel Barrat , Jean Ribstein (1) , Bernard Combe (4) , Jacques Morel (4) , Claire Daien (4) , Claire I. Daien (4)

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 Service de rhumatologie
3 UNH - Unité de Nutrition Humaine
4 IGMM - Institut de Génétique Moléculaire de Montpellier

OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849\textpm1,350 vs. 2,182\textpm751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028). CONCLUSION: Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.

Mots clés: Sodium; Severity of Illness Index; Humans; Female; Male; Middle Aged; Arthritis; Rheumatoid; Case-Control Studies

Domaines: Sciences du Vivant [q-bio]

Sarah Marouen, Guilhem Du Cailar, Rachel Audo, Cedric Lukas, Gaëlle Vial, et al.. Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls. PLoS ONE, 2017, 12 (10), pp.e0186157. ⟨10.1371/journal.pone.0186157⟩. ⟨hal-01743652⟩