Calpains as potential anti-cancer targets

Calpains as potential anti-cancer targets.

Ludovic Leloup (1) , Alan Wells (2)

1 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
2 PITT - University of Pittsburgh

The intracellular signaling cysteine proteases, calpains (specifically the ubiquitous calpains 1 and 2), are involved in numerous physiological and pathological phenomena. Several works have highlighted the implication of calpains in processes crucial for cancer development and progression. For these reasons, calpains are considered by several authors as potential anti-cancer targets.

Domaines: Sciences du Vivant [q-bio]; Cancer

Ludovic Leloup, Alan Wells. Calpains as potential anti-cancer targets. Expert Opinion on Therapeutic Targets, 2011, 15 (3), pp.309 - 323. ⟨10.1517/14728222.2011.553611⟩. ⟨hal-01740915⟩