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Communication Dans Un Congrès Année : 2004

Coating of nanoparticles using a supercritical anti solvent (SAS) process

Résumé

Nanoparticles represent a new field of interest especially for pharmaceutical applications such as controlled release or specific target delivery. Because of their high specific surface area, they are not easy to encapsulate. This paper deals with nanoencapsulation of silica particles using the SAS process. The co-injection of the silica particles dispersed in an organic polymeric solution and of supercritical CO 2 induces the solidification of the coating agent onto the silica nanoparticles, then forming nanocapsules. Two common polymers used in the pharmaceutical industry were chosen as coating agents. Hydrophilic nanoparticles were investigated so as to evaluate polymer/model particle interactions. We have worked with hypromellose phthalate HPMCP and ethylcellulose EC. The organic solvents used were acetone and ethanol. The coating experiments using supercritical CO 2 were performed in a semi continuous process. Before injecting, the mixture of silica particles and dissolved polymer into organic solution was dispersed by sonication. Once pressure and temperature conditions in the vessel are established, the injection started. Then the last stage was an extraction of the residual solvent in the coated nanoparticles. The CO 2 /solvent mixture was continuously separated by adjusting pressure and temperature conditions in the cyclonic separators. Different parameters were adjusted to obtain a successful coating of nanoparticles. Both polymer/silica and CO 2 /organic solution ratios, pressure and the way to bring into contact the polymeric organic suspension with the silica particles have been tested. Perkin Elmer Fourier Transform Infrared Spectrophotometer (FT-IR) and BET specific surface area were used to evaluate encapsulation efficiency. ESEM was used for morphological visualisations.
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Dates et versions

hal-01740788 , version 1 (22-03-2018)

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  • HAL Id : hal-01740788 , version 1

Citer

Marilyn Calderone, Élisabeth Rodier, Bernard Freiss, Jean‐jacques Letourneau, Jacques Fages. Coating of nanoparticles using a supercritical anti solvent (SAS) process. 7th Italian Conference on Supercritical Fluids and Their Applications - 9th Meeting on Supercritical Fluids, ISASF - DICAMP University of Trieste, Jun 2004, Trieste, Italy. 6 p. ⟨hal-01740788⟩
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