Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling

Chloé Terciolo , Aurélie Dobric , Mehdi Ouaissi (1) , Carole Siret (1) , Gilles Breuzard (1) , Françoise Silvy (1) , Bastien Marchiori , Sébastien Germain , Renaté Bonier , Adel Hama (2) , Róisín Owens (2) , Dominique Lombardo (1) , Veronique Rigot (1) , Frédéric André (1)

1 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
2 BEL-ENSMSE - Département Bioélectronique

Alteration in intestinal permeability is the main factor underlying the pathogenesis of many diseases affecting the gut, such as inflammatory bowel disease [IBD]. Characterization of molecules targeting the restoration of intestinal barrier integrity is therefore vital for the development of alternative therapies. The yeast Saccharomyces boulardii CNCM I-745 [Sb], used to prevent and treat antibiotic-associated infectious and functional diarrhea, may have a beneficial effect in the treatment of IBD.

Mots clés: Adherens junction; inflammatory bowel disease; intestinal permeability

Domaines: Sciences du Vivant [q-bio]

Chloé Terciolo, Aurélie Dobric, Mehdi Ouaissi, Carole Siret, Gilles Breuzard, et al.. Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling. Journal of Crohn's and Colitis, 2017, 11 (8), pp.999 - 1010. ⟨10.1093/ecco-jcc/jjx030⟩. ⟨hal-01739586⟩