In vivo high resolution human corneal imaging using full-field optical coherence tomography

Viacheslav Mazlin (1) , Peng Xiao (1) , Eugénie Dalimier (2) , Kate Grieve (3, 4) , Kristina Irsch (3, 4, 5) , José-Alain Sahel (4, 3, 6) , Mathias Fink (1) , A. Claude Boccara (1, 2)

1 IL - Institut Langevin - Ondes et Images (UMR7587)
2 LLTech SAS Paris
3 Institut de la Vision
4 CHNO - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
5 Wilmer Eye Institute
6 University of Pittsburgh School of Medicine

We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman's layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet's membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm – a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics.

Domaines: Imagerie; Organes des sens

Viacheslav Mazlin, Peng Xiao, Eugénie Dalimier, Kate Grieve, Kristina Irsch, et al.. In vivo high resolution human corneal imaging using full-field optical coherence tomography. Biomedical optics express, 2018, 9 (2), pp.557-568. ⟨10.1364/BOE.9.000557⟩. ⟨hal-01737927⟩