Stricturing Crohn's disease-like colitis in a patient treated with belatacept

Anne Bozon (1) , Guillaume Jeantet (1) , Benjamin Rivière (1) , Natalie Funakoshi (1, 2) , Gaspard Dufour (1) , Roman Combes (1, 2) , Jean-Christophe Valats (1) , Sylvie Delmas (1) , Jean Emmanuel Serre (1) , Michael Bismuth (1) , Jeanne Ramos (1) , Moglie Le Quintrec (1, 2) , Pierre Blanc (1, 2) , Guillaume Pineton de Chambrun (1)

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) modifying agents have been involved in the development of intestinal inflammation, especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept, a recombinant CTLA-4-Ig fusion protein.

Mots clés: Crohn's disease; Colitis; Belatacept; Inflammatory bowel disease; HHV-6

Domaines: Hépatologie et Gastroentérologie; Immunothérapie

Anne Bozon, Guillaume Jeantet, Benjamin Rivière, Natalie Funakoshi, Gaspard Dufour, et al.. Stricturing Crohn's disease-like colitis in a patient treated with belatacept. World Journal of Gastroenterology, 2017, 23 (48), pp.8660--8665. ⟨10.3748/wjg.v23.i48.8660⟩. ⟨hal-01724131⟩