A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: Syringe-foaming using a viscous hydrophilic polymeric solution

Jingtao Zhang (1, 2) , Weizhen Liu (1, 2) , Olivier Gauthier (2) , Sophie Sourice (2) , Paul Pilet (3, 2) , Gildas Réthoré (2) , Khalid Khairoun (1, 2) , Jean-Michel Bouler (1) , Franck Tancret (4) , Pierre Weiss (2)

1 LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire
2 RMeS - Regenerative Medicine and Skeleton
3 Matériaux d'intérêt biologique
4 IMN - Institut des Matériaux Jean Rouxel

In this study, we propose a simple and effective strategy to prepare injectable macroprous calcium phosphate cements (CPCs) by syringe-foaming via hydrophilic viscous polymeric solution, such as using silanized-hydroxypropyl methylcellulose (Si-HPMC) as a foaming agent. The Si-HPMC foamed CPCs demonstrate excellent handling properties such as injectability and cohesion. After setting the foamed CPCs possess hierarchical macropores and their mechanical properties (Young's modulus and compressive strength) are comparable to those of cancellous bone. Moreover, a preliminary in vivo study in the distal femoral sites of rabbits was conducted to evaluate the biofunctionality of this injectable macroporous CPC. The evidence of newly formed bone in the deep zone of implantation site indicates the feasibility and effectivity of this foaming strategy. Finally, the optimizing hydrogel formulation and alternative viscous hydrophilic polymers have been considered.

Mots clés: Calcium phosphate cements; Si-HPMC hydrogel; Silated polymer; Macropores; Bone regeneration

Domaines: Biomatériaux; Polymères

Jingtao Zhang, Weizhen Liu, Olivier Gauthier, Sophie Sourice, Paul Pilet, et al.. A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: Syringe-foaming using a viscous hydrophilic polymeric solution. Acta Biomaterialia, 2016, 31, pp.326-338. ⟨10.1016/j.actbio.2015.11.055⟩. ⟨hal-01723572⟩