L. L. Rubin and J. M. Staddon, THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER, Annual Review of Neuroscience, vol.22, issue.1, pp.11-28, 1999.
DOI : 10.1146/annurev.neuro.22.1.11

N. J. Abbott, Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation, Cellular and Molecular Neurobiology, vol.531, issue.Suppl. 579, pp.5-23, 2005.
DOI : 10.1007/978-3-642-76894-1_14

R. Cecchelli, Modelling of the blood???brain barrier in drug discovery and development, Nature Reviews Drug Discovery, vol.90, issue.8, pp.650-61, 2007.
DOI : 10.1016/S0002-9440(10)65511-3
URL : https://hal.archives-ouvertes.fr/hal-00543630

M. Pekny, K. A. Stanness, C. Eliasson, C. Betsholtz, and D. Janigro, Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAB-deficient mice, Glia, vol.112, issue.4, pp.390-400, 1998.
DOI : 10.1161/01.RES.73.3.448

H. Girouard and C. Iadecola, Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease, Journal of Applied Physiology, vol.100, issue.1, pp.328-363, 2006.
DOI : 10.1038/nn980

M. P. Dehouck, S. Méresse, P. Delorme, J. C. Fruchart, and R. Cecchelli, An Easier, Reproducible, and Mass-Production Method to Study the Blood?Brain Barrier In Vitro, Journal of Neurochemistry, vol.214, issue.5, pp.1798-801, 1990.
DOI : 10.1002/jemt.1060010412
URL : https://hal.archives-ouvertes.fr/hal-00523911

M. Culot, An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening, Toxicology in Vitro, vol.22, issue.3, pp.799-811, 2008.
DOI : 10.1016/j.tiv.2007.12.016
URL : https://hal.archives-ouvertes.fr/hal-00527560

Y. Zhang, Porcine Brain Microvessel Endothelial Cells as an in Vitro Model to Predict in Vivo Blood-Brain Barrier Permeability, Drug Metabolism and Disposition, vol.34, issue.11, pp.1935-1978, 2006.
DOI : 10.1124/dmd.105.006437

A. Patabendige, R. A. Skinner, and N. J. Abbott, Establishment of a simplified in vitro porcine blood???brain barrier model with high transendothelial electrical resistance, Brain Research, vol.1521, pp.1-15, 2012.
DOI : 10.1016/j.brainres.2012.06.057

N. J. Abbott, D. E. Dolman, S. Drndarski, and S. M. Fredriksson, An Improved In Vitro Blood???Brain Barrier Model: Rat Brain Endothelial Cells Co-cultured with Astrocytes, Methods Mol Biol, vol.814, pp.415-445, 2012.
DOI : 10.1007/978-1-61779-452-0_28

S. Nakagawa, A new blood???brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes, Neurochemistry International, vol.54, issue.3-4, pp.253-63, 2009.
DOI : 10.1016/j.neuint.2008.12.002

I. Wilhelm, C. Fazakas, and I. A. Krizbai, In vitro models of the blood-brain barrier, Acta Neurobiol Exp (Wars), vol.71, issue.1, pp.113-141, 2011.

C. Coisne, Mouse syngenic in vitro blood???brain barrier model: a new tool to examine inflammatory events in cerebral endothelium, Laboratory Investigation, vol.148, issue.6, pp.734-780, 2005.
DOI : 10.1016/S0165-5728(02)00256-4
URL : https://hal.archives-ouvertes.fr/hal-00542810

V. Josserand, Evaluation of Drug Penetration into the Brain: A Double Study by in Vivo Imaging with Positron Emission Tomography and Using an in Vitro Model of the Human Blood-Brain Barrier, Journal of Pharmacology and Experimental Therapeutics, vol.316, issue.1, pp.79-86, 2006.
DOI : 10.1124/jpet.105.089102

O. Lacombe, Primary Human and Animal Cell-Based Blood???Brain Barrier Models as a Screening Tool in Drug Discovery, Molecular Pharmaceutics, vol.8, issue.3, pp.651-63, 2011.
DOI : 10.1021/mp1004614

S. Nakagawa, Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells, Cellular and Molecular Neurobiology, vol.7, issue.6, pp.687-94, 2007.
DOI : 10.1007/s10571-007-9195-4

E. S. Lippmann, C. Weidenfeller, C. N. Svendsen, and E. Shusta, Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons, Journal of Neurochemistry, vol.86, issue.3, pp.507-527, 2011.
DOI : 10.1046/j.1471-4159.2003.01826.x
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2011.07434.x/pdf

Q. Xue, A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat, International Journal of Biological Sciences, vol.9, issue.2, pp.174-89, 2013.
DOI : 10.7150/ijbs.5115

F. Sohet and R. Daneman, Genetic mouse models to study blood-brain barrier development and function. Fluids Barriers CNS, p.3, 2013.
DOI : 10.1186/2045-8118-10-3
URL : http://doi.org/10.1186/2045-8118-10-3

G. Shayan, Y. S. Choi, E. V. Shusta, M. L. Shuler, and K. H. Lee, Murine in vitro model of the blood???brain barrier for evaluating drug transport, European Journal of Pharmaceutical Sciences, vol.42, issue.1-2, pp.148-55, 2011.
DOI : 10.1016/j.ejps.2010.11.005

R. Cecchelli, In vitro model for evaluating drug transport across the blood???brain barrier, Advanced Drug Delivery Reviews, vol.36, issue.2-3, pp.165-178, 1999.
DOI : 10.1016/S0169-409X(98)00083-0
URL : https://hal.archives-ouvertes.fr/hal-00534832

M. A. Deli, C. S. Abrahám, Y. Kataoka, and M. Niwa, Permeability Studies on In Vitro Blood???Brain Barrier Models: Physiology, Pathology, and Pharmacology, Cellular and Molecular Neurobiology, vol.69, issue.3, pp.59-127, 2005.
DOI : 10.1152/ajpheart.00520.2003

N. Perrière, A functional in vitro model of rat blood???brain barrier for molecular analysis of efflux transporters, Brain Research, vol.1150, pp.1-1, 2007.
DOI : 10.1016/j.brainres.2007.02.091

W. M. Pardridge, J. L. Buciak, and P. M. Friden, Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo, J Pharmacol Exp Ther, vol.259, issue.1, pp.66-70, 1991.

C. Delbart, J. C. Fruchart, and R. Cecchelli, Low-density lipoprotein receptor on endothelium of brain capillaries, J Neurochem, vol.53, issue.2, pp.340-345, 1989.
URL : https://hal.archives-ouvertes.fr/hal-00523614

F. Gosselet, P. Candela, E. Sevin, V. Berezowski, R. Cecchelli et al., Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood???brain barrier: Use of an in vitro model, Brain Research, vol.1249, pp.34-42, 2009.
DOI : 10.1016/j.brainres.2008.10.036
URL : https://hal.archives-ouvertes.fr/hal-00543674

W. M. Pardridge, Vector-mediated drug delivery to the brain, Advanced Drug Delivery Reviews, vol.36, issue.2-3, pp.299-321, 1999.
DOI : 10.1016/S0169-409X(98)00087-8

W. M. Pardridge and R. J. Boado, Reengineering Biopharmaceuticals for Targeted Delivery Across the Blood???Brain Barrier, Methods Enzymol, vol.503, pp.269-92, 2012.
DOI : 10.1016/B978-0-12-396962-0.00011-2

R. J. Boado, J. Z. Lu, E. K. Hui, R. K. Sumbria, and W. M. Pardridge, Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor, Biotechnology and Bioengineering, vol.231, issue.5, pp.1456-65, 2013.
DOI : 10.1016/j.expneurol.2011.06.019

S. Ito, S. Ohtsuki, and T. Terasaki, Functional characterization of the brain-to-blood efflux clearance of human amyloid-?? peptide (1???40) across the rat blood???brain barrier, Neuroscience Research, vol.56, issue.3, pp.246-252, 2006.
DOI : 10.1016/j.neures.2006.07.006

M. Demeule, Identification and Design of Peptides as a New Drug Delivery System for the Brain, Journal of Pharmacology and Experimental Therapeutics, vol.324, issue.3, pp.1064-72, 2008.
DOI : 10.1124/jpet.107.131318

K. Yamada, Model of the Blood-Brain Barrier Cells, Journal of Biological Chemistry, vol.5, issue.50, pp.34554-62, 2008.
DOI : 10.1074/jbc.M008046200

R. Gabathuler, D??veloppement de nouveaux vecteurs prot??iniques pour le transport physiologique d???agents th??rapeutiques vers le syst??me nerveux central, Biologie Aujourd'hui, vol.206, issue.3, pp.191-203, 2012.
DOI : 10.1051/jbio/2012018

J. D. Malcor, Chemical Optimization of New Ligands of the Low-Density Lipoprotein Receptor as Potential Vectors for Central Nervous System Targeting, Journal of Medicinal Chemistry, vol.55, issue.5, pp.2227-2268, 2012.
DOI : 10.1021/jm2014919
URL : https://hal.archives-ouvertes.fr/hal-00839126

D. Wang, Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier, Proceedings of the National Academy of Sciences, vol.1188, issue.4, pp.2999-3004, 2013.
DOI : 10.1016/j.brainres.2007.10.036

B. J. Spencer and I. M. Verma, Targeted delivery of proteins across the blood-brain barrier, Proceedings of the National Academy of Sciences, vol.93, issue.21, pp.7594-7603, 2007.
DOI : 10.1073/pnas.93.21.11382

J. Kreuter, Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier, Journal of Drug Targeting, vol.10, issue.4, pp.317-342, 2002.
DOI : 10.1080/10611860290031877

S. M. Stamatovic, R. F. Keep, and A. Andjelkovic, Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier, Current Neuropharmacology, vol.6, issue.3, pp.179-92, 2008.
DOI : 10.2174/157015908785777210

M. A. Petty and E. H. Lo, Junctional complexes of the blood???brain barrier: permeability changes in neuroinflammation, Progress in Neurobiology, vol.68, issue.5, pp.311-334, 2002.
DOI : 10.1016/S0301-0082(02)00128-4

D. Stephan, TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier, Journal of Neuroinflammation, vol.41, issue.Pt 2, 2013.
DOI : 10.3109/08820139.2011.604863
URL : https://hal.archives-ouvertes.fr/inserm-00787290

L. Descamps, R. Cecchelli, and G. Torpier, Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers, Journal of Neuroimmunology, vol.74, issue.1-2, pp.173-84, 1997.
DOI : 10.1016/S0165-5728(96)00226-3
URL : https://hal.archives-ouvertes.fr/hal-00524687

F. Miller, blood-brain barrier model, European Journal of Neuroscience, vol.78, issue.4, pp.835-879, 2005.
DOI : 10.1093/infdis/151.3.535
URL : https://hal.archives-ouvertes.fr/hal-00543167

C. Fillebeen, B. Dehouck, M. Benaïssa, I. Dhennin-duthille, R. Cecchelli et al., Tumor Necrosis Factor-?? Increases Lactoferrin Transcytosis Through the Blood-Brain Barrier, Journal of Neurochemistry, vol.70, issue.6, pp.2491-500, 1999.
DOI : 10.1016/0165-5728(94)90193-7
URL : https://hal.archives-ouvertes.fr/hal-00525285

Y. Zhang, J. D. Schuetz, W. F. Elmquist, and D. W. Miller, Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells, Journal of Pharmacology and Experimental Therapeutics, vol.311, issue.2, pp.449-55, 2004.
DOI : 10.1124/jpet.104.068528

R. L. Kane, I. Martínez-lópez, M. R. Dejoseph, J. R. Viña, and R. A. Hawkins, -dependent Glutamate Transporters (EAAT1, EAAT2, and EAAT3) of the Blood-Brain Barrier, Journal of Biological Chemistry, vol.18, issue.45, pp.31891-31896, 1999.
DOI : 10.1016/S0042-6989(97)00452-5

R. Kannan, A. Mittur, Y. Bao, T. Tsuruo, and N. Kaplowitz, GSH Transport in Immortalized Mouse Brain Endothelial Cells, Journal of Neurochemistry, vol.201, issue.1, pp.390-399, 1999.
DOI : 10.1006/bbrc.1994.1715

N. J. Abbott, C. C. Hughes, P. A. Revest, and J. Greenwood, Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier, J Cell Sci, vol.103, issue.1, pp.23-37, 1992.

N. Perrière, Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties, Journal of Neurochemistry, vol.17, issue.2, pp.279-89, 2005.
DOI : 10.1038/ki.1995.123

R. Tsou and F. Isik, Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells, Molecular and Cellular Biochemistry, vol.224, issue.1/2, pp.81-90, 2001.
DOI : 10.1023/A:1011947301849

H. C. Helms, H. S. Waagepetersen, C. U. Nielsen, and B. Brodin, Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood???Brain Barrier Model by Increasing Media Buffer Capacity During Growth, The AAPS Journal, vol.12, issue.4, pp.759-70, 2010.
DOI : 10.1208/s12248-010-9237-6

L. L. Rubin and J. Sanes, Neuronal and glial cell biology, Current Opinion in Neurobiology, vol.6, issue.5, pp.573-578, 1996.
DOI : 10.1016/S0959-4388(96)80087-0

N. J. Abbott, Astrocyte???endothelial interactions at the blood???brain barrier, Nature Reviews Neuroscience, vol.15, issue.1, pp.41-53, 2006.
DOI : 10.1046/j.1469-7580.2002.00065.x

B. Deracinois, Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study, PROTEOMICS, vol.279, issue.7, pp.1185-99, 2013.
DOI : 10.1074/jbc.M402835200

R. F. Haseloff, I. E. Blasig, H. C. Bauer, and H. Bauer, In Search of the Astrocytic Factor(s) Modulating Blood???Brain Barrier Functions in Brain Capillary Endothelial Cells In Vitro, Cellular and Molecular Neurobiology, vol.101, issue.Pt 1, pp.25-39, 2005.
DOI : 10.1161/01.STR.30.8.1671

H. Mi, H. Haeberle, and B. A. Barres, Induction of Astrocyte Differentiation by Endothelial Cells, The Journal of Neuroscience, vol.21, issue.5, pp.1538-1585, 2001.
DOI : 10.1523/JNEUROSCI.21-05-01538.2001

N. J. Abbott, Astrocyte-endothelial interactions and blood-brain barrier permeability*, Journal of Anatomy, vol.200, issue.6, pp.629-638, 2002.
DOI : 10.1046/j.1469-7580.2002.00064.x

A. R. Calabria, C. Weidenfeller, A. R. Jones, H. E. De-vries, and E. Shusta, Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction, Journal of Neurochemistry, vol.7, issue.4, pp.922-955, 2006.
DOI : 10.1128/IAI.69.2.845-852.2001

C. Förster, system, The Journal of Physiology, vol.275, issue.Suppl. 2, p.475, 2005.
DOI : 10.1074/jbc.M910373199

C. Förster, J. Waschke, M. Burek, J. Leers, and D. Drenckhahn, Glucocorticoid effects on mouse microvascular endothelial barrier permeability are brain specific, The Journal of Physiology, vol.70, issue.Suppl. 2, p.413, 2006.
DOI : 10.1016/j.steroids.2005.02.006

S. Ge and J. S. Pachter, Isolation and culture of microvascular endothelial cells from murine spinal cord, Journal of Neuroimmunology, vol.177, issue.1-2, pp.209-223, 2006.
DOI : 10.1016/j.jneuroim.2006.05.012

V. Berezowski, C. Landry, M. P. Dehouck, R. Cecchelli, and L. Fenart, Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood???brain barrier, Brain Research, vol.1018, issue.1, pp.1-9, 2004.
DOI : 10.1016/j.brainres.2004.05.092
URL : https://hal.archives-ouvertes.fr/hal-00540890

S. Duan, C. M. Anderson, B. A. Stein, and R. A. Swanson, Glutamate Induces Rapid Upregulation of Astrocyte Glutamate Transport and Cell-Surface Expression of GLAST, The Journal of Neuroscience, vol.19, issue.23, pp.10193-200, 1999.
DOI : 10.1523/JNEUROSCI.19-23-10193.1999

G. Gegelashvili, Y. Dehnes, N. C. Danbolt, and A. Schousboe, The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms, Neurochemistry International, vol.37, issue.2-3, pp.163-70, 2000.
DOI : 10.1016/S0197-0186(00)00019-X

P. Candela, Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro, Endothelium, vol.40, issue.5-6, pp.5-6, 2008.
DOI : 10.1016/S1537-1891(02)00200-8
URL : https://hal.archives-ouvertes.fr/hal-00543686

B. Dehouck, M. P. Dehouck, J. C. Fruchart, and R. Cecchelli, Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes, The Journal of Cell Biology, vol.126, issue.2, pp.465-73, 1994.
DOI : 10.1083/jcb.126.2.465
URL : https://hal.archives-ouvertes.fr/hal-00530659

B. Dehouck, L. Fenart, M. P. Dehouck, A. Pierce, G. Torpier et al., A New Function for the LDL Receptor: Transcytosis of LDL across the Blood???Brain Barrier, The Journal of Cell Biology, vol.141, issue.4, pp.877-89, 1997.
DOI : 10.1007/BF01181571
URL : https://hal.archives-ouvertes.fr/hal-00531727

D. J. Mahad and R. M. Ransohoff, The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), Seminars in Immunology, vol.15, issue.1, pp.23-32, 2003.
DOI : 10.1016/S1044-5323(02)00125-2

A. R. Glabinski and R. M. Ransohoff, Chemokines and chemokine receptors in CNS pathology, Journal of Neurovirology, vol.5, issue.1, pp.3-12, 1999.
DOI : 10.3109/13550289909029740

S. M. Stamatovic, Monocyte Chemoattractant Protein-1 Regulation of Blood???Brain Barrier Permeability, Journal of Cerebral Blood Flow & Metabolism, vol.277, issue.5, pp.593-606, 2005.
DOI : 10.1016/S0169-328X(99)00007-8

B. D. Semple, T. Kossmann, and M. C. Morganti-kossmann, Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks, Journal of Cerebral Blood Flow & Metabolism, vol.4, issue.3, pp.459-73, 2010.
DOI : 10.1016/S1074-7613(00)80165-X

S. Veszelka, S. Nakagawa, M. Niwa, and M. A. Deli, Patented in vitro blood-brain barrier models in CNS drug discovery, Recent Pat CNS Drug Discov, vol.6, issue.2, pp.107-118, 2011.

A. Patabendige, The value of in vitro models of the blood-brain barrier and their uses, Altern Lab Anim, vol.40, issue.6, pp.335-343, 2012.

O. Ogunshola, In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity, Current Pharmaceutical Design, vol.17, issue.26, pp.2755-61, 2011.
DOI : 10.2174/138161211797440159

E. Vandenhaute, Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes, Current Neurovascular Research, vol.8, issue.4, pp.258-69, 2011.
DOI : 10.2174/156720211798121016

R. Shawahna, X. Decleves, and J. M. Scherrmann, Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: a special focus on transporters and metabolizing enzymes, Curr Drug Metab, vol.14, issue.1, pp.120-156, 2013.

H. Vernon, K. Clark, and J. P. Bressler, In Vitro Models to Study the Blood Brain Barrier, Methods Mol Biol, vol.758, pp.153-68, 2011.
DOI : 10.1007/978-1-61779-170-3_10

A. R. Calabria and E. Shusta, Brain Microvascular Endothelial Cells, Journal of Cerebral Blood Flow & Metabolism, vol.63, issue.2, pp.135-183, 2008.
DOI : 10.1046/j.1600-0420.2003.00178.x

Y. Uchida, S. Ohtsuki, J. Kamiie, and T. Terasaki, Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice, Journal of Pharmacology and Experimental Therapeutics, vol.339, issue.2, pp.579-88, 2011.
DOI : 10.1124/jpet.111.184200

L. Cucullo, B. Aumayr, E. Rapp, and D. Janigro, Drug delivery and in vitro models of the blood-brain barrier, Curr Opin Drug Discov Devel, vol.8, issue.1, pp.89-99, 2005.

P. Naik and L. Cucullo, In Vitro Blood???Brain Barrier Models: Current and Perspective Technologies, Journal of Pharmaceutical Sciences, vol.101, issue.4, pp.1337-54, 2012.
DOI : 10.1002/jps.23022

K. A. Stanness, A new model of the blood???brain barrier, NeuroReport, vol.10, issue.18, pp.3725-3756, 1999.
DOI : 10.1097/00001756-199912160-00001

S. Santaguida, Side by side comparison between dynamic versus static models of blood???brain barrier in vitro: A permeability study, Brain Research, vol.1109, issue.1, pp.1-13, 2006.
DOI : 10.1016/j.brainres.2006.06.027

L. Cucullo, N. Marchi, M. Hossain, and D. Janigro, BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System, Journal of Cerebral Blood Flow & Metabolism, vol.17, issue.2, pp.767-77, 2011.
DOI : 10.1111/j.1528-1157.1996.tb00586.x

L. Cucullo, . M. Hossain, V. Puvenna, N. Marchi, and D. Janigro, The role of shear stress in Blood-Brain Barrier endothelial physiology, BMC Neuroscience, vol.12, issue.1, 2011.
DOI : 10.1111/j.1528-1167.2006.00960.x

L. Cucullo, M. Hossain, W. Tierney, and D. Janigro, A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box, BMC Neuroscience, vol.14, issue.1, p.18, 2013.
DOI : 10.1016/j.brainres.2004.04.034

A. A. Qutub and C. A. Hunt, Glucose transport to the brain: A systems model, Brain Research Reviews, vol.49, issue.3, pp.595-617, 2005.
DOI : 10.1016/j.brainresrev.2005.03.002

W. Neuhaus, A novel flow based hollow-fiber blood???brain barrier in vitro model with immortalised cell line PBMEC/C1???2, Journal of Biotechnology, vol.125, issue.1, pp.127-168, 2006.
DOI : 10.1016/j.jbiotec.2006.02.019

F. Roux and P. Couraud, Rat Brain Endothelial Cell Lines for the Study of Blood???Brain Barrier Permeability and Transport Functions, Cellular and Molecular Neurobiology, vol.97, issue.6, pp.41-58, 2005.
DOI : 10.1016/S0304-4165(96)00131-6

B. B. Weksler, Blood-brain barrier-specific properties of a human adult brain endothelial cell line, The FASEB Journal, vol.19, issue.13, pp.1872-1876, 2005.
DOI : 10.1096/fj.04-3458fje

Y. Omidi, Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood???brain barrier model for drug uptake and transport studies, Brain Research, vol.990, issue.1-2, pp.95-112, 2003.
DOI : 10.1016/S0006-8993(03)03443-7

B. Weksler, I. A. Romero, and P. Couraud, The hCMEC/D3 cell line as a model of the human blood brain barrier. Fluids Barriers CNS, p.16, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00812147

L. Cucullo, Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies, Journal of Cerebral Blood Flow & Metabolism, vol.19, issue.2, pp.312-340, 2008.
DOI : 10.1111/j.1749-6632.1994.tb17311.x