Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System

Emilie Duchalais (1) , Christophe Guilluy (2) , Steven Nedellec (3) , Mélissa Touvron (4, 1) , Anne Bessard (1) , Yann Touchefeu (1) , Céline Bossard (5) , Hélène Boudin (1) , Guy Louarn (6) , Michel Neunlist (1) , Laurianne van Landeghem (1)

1 TENS - The Enteric Nervous System in gut and brain disorders [U1235]
2 ITX - ITX - unité de recherche de l'institut du thorax
3 Plateforme MicroPicel
4 EPHE - École Pratique des Hautes Études
5 Laboratoire d'anatomie et cytologie pathologiques
6 IMN - Institut des Matériaux Jean Rouxel

These findings show that colorectal cancer cells adhere to and migrate along enteric neurons partly via L1CAM and N-cadherin. Thus, the dense network of local enteric neurons in the tumor microenvironment may serve as the local route for colorectal cancer spreading.

Domaines: Science des matériaux [cond-mat.mtrl-sci]

Emilie Duchalais, Christophe Guilluy, Steven Nedellec, Mélissa Touvron, Anne Bessard, et al.. Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System. Cellular and Molecular Gastroenterology and Hepatology, 2018, 5 (1), pp.31 - 49. ⟨10.1016/j.jcmgh.2017.10.002⟩. ⟨hal-01718258⟩