Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3

Suenia de Paiva Lacerda (1) , N. N. P. Cerize , Maria-Inês Ré (1)

1 RAPSODEE - Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement

Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high-pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone-3-loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone-3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in vitro release and stability of benzophenone-3-loaded in these NLCs. A loading capacity of approximately 5% of benzophenone-3 (m(BZ-3)/m(lipids)) was characteristic of these systems.

Mots clés: nanostructured lipid carriers; carnauba wax; isodecyl oleate; benzophenone-3; dispersions

Domaines: Pharmacie galénique; Génie des procédés

Suenia de Paiva Lacerda, N. N. P. Cerize, Maria-Inês Ré. Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3. International Journal of Cosmetic Science, 2011, 33 (4), pp.312-321. ⟨10.1111/j.1468-2494.2010.00626.x⟩. ⟨hal-01717486⟩