Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin

Florina Teodorescu (1) , Gurvan Queniat (2) , Catherine Foulon (3) , Marie Lecoeur (3) , Alexandre Barras (4) , Samia Boulahneche (1) , Mohmaed Salah Medjram (5) , Thomas Hubert (6) , Amar Abderrahmani (7) , Rabah Boukherroub (1) , Sabine Szunerits (1)

1 IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
2 RNMCD - Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011
3 GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365
4 IBLI - Institut de biologie de Lille - IBL
5 Université 20 Août 1955 Skikda
6 RTD - Recherche translationnelle sur le diabète - U 1190
7 EGENODIA (GI3M) - Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283

The development of a skin-mounted patch capable of controlled transcutaneous delivery of therapeutics through thermal activation provides a unique solution for the controlled release of active principles over long-term periods. Here, we report on a flexible transdermal patch for photothermal triggered release of ondansetron (ODS), a commonly used drug for the treatment of chemotherapy-induced nausea and vomiting and used as model compound here. To achieve this, a dispersion of ODS-loaded reduced graphene oxide (rGO-ODS) nanosheets were deposited onto Kapton to produce a flexible polyimide-based patch. It is demonstrated that ODS loaded Kapton/rGO patches have a high drug delivery performance upon irradiation with a continuous laser beam at 980 nm for 10 min due to an induced photothermal heating effect. The ability of ODS impregnated Kapton/rGO patches as transdermal delivery scaffolds for ODS across the skin is in addition investigated using porcine ear skin as a model. We show that the cumulative quantity and flux of ODS passing the skin are highly depending on the laser power density used. At 5 W cm − 2 irradiation, the ODS flux across pig skin was determined to be 1.6 μg cm − 2 h − 1 comparable to other approaches. The use of tween 20 as skin enhancer could significantly increase the ODS flux to 13.2 μg cm − 2 h − 1. While the skin penetration enhancement is comparable to that obtained using other well-known permeation enhancers, the actual superiority and interest of the proposed approach is that the Kapton/rGO photoactivatable skin patch can be loaded with any drugs and therapeutics of interest, making the approach extremely versatile. The on demand delivery of drugs upon local laser irradiation and the possibility to reload the interface with the drug makes this new drug administration route very appealing.

Domaines: Chimie thérapeutique; Pharmacie galénique

Florina Teodorescu, Gurvan Queniat, Catherine Foulon, Marie Lecoeur, Alexandre Barras, et al.. Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin. Journal of Controlled Release, 2017, 245, pp.137-146. ⟨10.1016/j.jconrel.2016.11.029⟩. ⟨hal-01693302⟩