Peptidoglycan recognition proteins: modulators of the microbiome and inflammation

Julien Royet (1) , Dipika Gupta , Roman Dziarski

1 IBDM - Institut de Biologie du Développement de Marseille

All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.

Domaines: Biologie du développement; Biologie cellulaire

Julien Royet, Dipika Gupta, Roman Dziarski. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nature Reviews Immunology, 2011, 11 (12), pp.837 - 851. ⟨10.1038/nri3089⟩. ⟨hal-01692785⟩