Skip to Main content Skip to Navigation
Journal articles

Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy

Abstract : Selective killing of cancer cells while minimizing damage to healthy tissues is the goal of clinical radiation therapy. This therapeutic ratio can be improved by image-guided radiation delivery and selective radiosensitization of cancer cells. Here, we have designed and tested a novel trimodal theranostic nanoparticle made of bismuth and gadolinium for on-site radiosensitization and image contrast enhancement to improve the efficacy and accuracy of radiation therapy. We demonstrate in vivo magnetic resonance (MR), computed tomography (CT) contrast enhancement, and tumor suppression with prolonged survival in a non-small cell lung carcinoma model during clinical radiation therapy. Histological studies show minimal off-target toxicities due to the nanoparticles or radiation. By mimicking existing clinical workflows, we show that the bismuth–gadolinium nanoparticles are highly compatible with current CT-guided radiation therapy and emerging MR-* Corresponding Authors:
Complete list of metadatas

Cited literature [36 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01689566
Contributor : Béatrice Rayet <>
Submitted on : Monday, January 22, 2018 - 11:33:31 AM
Last modification on : Thursday, October 15, 2020 - 8:54:03 AM
Long-term archiving on: : Thursday, May 24, 2018 - 7:30:17 AM

File

nihms874111.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Alexandre Detappe, Eloise Thomas, Mark Tibbitt ||, Sijumon Kunjachan, Oksana Zavidij, et al.. Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy. Nano Letters, American Chemical Society, 2017, 17 (3), pp.1733 - 1740. ⟨10.1021/acs.nanolett.6b05055⟩. ⟨hal-01689566⟩

Share

Metrics

Record views

247

Files downloads

263