Biochip based on arrays of switchable magnetic nano-traps

Christopher Vautrin (1) , Maria Vyazmensky (2) , Stanislav Engel (2) , Stephan Mc. Murtry (1) , Michel Hehn (1) , François Montaigne (1) , Daniel Lacour (1) , Robert Marks (2, 3)

1 IJL - Institut Jean Lamour
2 BGU - Ben-Gurion University of the Negev
3 Nanyang Technological University [Singapour]

Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.

Mots clés: Bio-assay; Peptide; Magnetic domains walls; Magnetic nano-traps; Magnetic beads

Domaines: Science des matériaux [cond-mat.mtrl-sci]; Biochimie [q-bio.BM]

Christopher Vautrin, Maria Vyazmensky, Stanislav Engel, Stephan Mc. Murtry, Michel Hehn, et al.. Biochip based on arrays of switchable magnetic nano-traps. Sensors and Actuators B: Chemical, 2017, 251, pp.699-705. ⟨10.1016/j.snb.2017.05.084⟩. ⟨hal-01686947⟩