Fast Inference of Individual Admixture Coefficients Using Geographic Data

Abstract : Accurately evaluating the distribution of genetic ancestry across geographic space is one of the main questions addressed by evolutionary biologists. This question has been commonly addressed through the application of Bayesian estimation programs allowing their users to estimate individual admixture proportions and allele frequencies among putative ancestral populations. Following the explosion of high-throughput sequencing technologies, several algorithms have been proposed to cope with computational burden generated by the massive data in those studies. In this context, incorporating geographic proximity in ancestry estimation algorithms is an open statistical and computational challenge. In this study, we introduce new algorithms that use geographic information to estimate ancestry proportions and ancestral genotype frequencies from population genetic data. Our algorithms combine matrix factorization methods and spatial statistics to provide estimates of ancestry matrices based on least-squares approximation. We demonstrate the benefit of using spatial algorithms through extensive computer simulations, and we provide an example of application of our new algorithms to a set of spatially referenced samples for the plant species Arabidopsis thaliana. Without loss of statistical accuracy, the new algorithms exhibit runtimes that are much shorter than those observed for previously developed spatial methods. Our algorithms are implemented in the R package, tess3r.
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Article dans une revue
Annals Of Applied Statistics, Institute Mathematical Statistics, A Paraître, 〈10.1101/080291〉
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https://hal.archives-ouvertes.fr/hal-01679877
Contributeur : Flora Jay <>
Soumis le : mercredi 10 janvier 2018 - 11:50:35
Dernière modification le : vendredi 12 janvier 2018 - 01:41:01

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Kevin Caye, Flora Jay, Olivier Michel, Olivier François. Fast Inference of Individual Admixture Coefficients Using Geographic Data. Annals Of Applied Statistics, Institute Mathematical Statistics, A Paraître, 〈10.1101/080291〉. 〈hal-01679877〉

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