Assessing Tumor-infiltrating Lymphocytes in Solid Tumors

Maria John Roberto Salgado 1 Thomas Gevaert Prudence A Russell Tom John Bibhusal Thapa Michael Christie Koen van de Vijver M V Estrada Paula I Gonzalez-Ericsson Melinda Sanders Benjamin Solomon 2 Cinzia Solinas Gert G G M van den Eynden Yves Allory 3 Matthias Preusser Johannes Hainfellner Giancarlo Pruneri 4 Andre Vingiani Sandra Demaria Fraser Symmans Paolo Nuciforo 5 Laura Comerma E A Thompson Sunil Lakhani Seong-Rim Kim Stuart Schnitt Cecile Colpaert Christos Sotiriou 1 Stefan Scherer 6 Michail Ignatiadis 7 Sunil Badve Robert H Pierce Giuseppe Viale 8 Nicolas Sirtaine Fred Penault-Llorca 9, 10 Tomohagu Sugie Susan Fineberg Soonmyung Paik Ashok Srinivasan Andre Richardson Yihong Wang Ewa Chmielik Jane Brock Douglas B Johnson Justin Balko Stephan Wienert Veerle Bossuyt Stefan Michiels 11, 12 Nils Ternès 12 Nicole Burchardi Stephen Luen Peter Savas Fred Klauschen Peter H Watson Brad H Nelson 13 Carmen Criscitiello Sandra O'Toole Denis Larsimont 14 Roland de Wind Giuseppe Curigliano 15 Fabrice André 16 Magali Lacroix-Triki 17 Mark van de Vijver Federico Rojo Giuseppe Floris Shahinaz Bedri Joseph Sparano David Rimm Torsten Nielsen Zuzana Kos Stephen Hewitt Baljit Singh Gelareh Farshid Sibylle Loi Kimberly H Allison Nadine Tung Sylvia Adams Karen Willard-Gallo Hugo M Horlings Leena Gandhi Andre Moreira 18 Fred Hirsch 19 Maria Dieci Maria Urbanowicz Iva Brcic Konstanty Korski Fabien Gaire Hartmut Koeppen Amy Lo Jennifer Giltnane Marlon C Rebelatto Keith E Steele Jiping Zha Kenneth Emancipator Jonathan W Juco Carsten Denkert 20 Jorge Reis-Filho 21 Sherene Loi 1 Stephen B Fox Shona Hendry Prudence A. Russell M.V. Estrada Paula I. Gonzalez-Ericsson Gert G.G.M. van den Eynden E.A. Thompson Robert H. Pierce 22 Douglas B. Johnson 23 Peter H. Watson Brad H. Nelson Sandra O’toole Kimberly H. Allison Hugo M. Horlings Marlon C. Rebelatto Keith E. Steele Jonathan W. Juco Stephen B. Fox 24
Abstract : Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.
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Submitted on : Thursday, January 4, 2018 - 11:25:59 AM
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Maria John, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, et al.. Assessing Tumor-infiltrating Lymphocytes in Solid Tumors. Advances in Anatomic Pathology, Lippincott, Williams & Wilkins, 2017, 24 (5), pp.235 - 251. ⟨10.1097/PAP.0000000000000162⟩. ⟨hal-01675241⟩



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