Relationship between cerebral aneurysm wall stiffness and rupture risk

Hervé Brunel (1, 2) , Dominique Ambard (2) , H. Dufour (1) , P. H. Roche (1) , Vincent Costalat (3) , Franck Jourdan (2)

1 CHU Marseille
2 BIOTIC - Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules
3 CHU Montpellier

Haemorrhage stroke is a major issue for public health care. The prevalence of intracranial aneurysms in the general population ranges between 3 and 6.6% (Wardlaw and White 2000). Fortunately, very few aneurysms rupture. The incidence of ruptured aneurysms is approximately 0.5% per year. However, patients are stressful and wants to be treated. But, endovascular treatment of unruptured aneurysms, which is the safest treatment, is not without risk and has about 1% mortality rate (Sluzewski et al. 2001). So, unruptured intracranial aneurysms represent a dilemma for the physicians. In 2011 (Costalat et al.), we have proposed an indicator base on the relationship between the mechanical properties of wall aneurysm tissues and the rupture risk. First conclusions suggested that the softer tissue is, the higher rupture risk is. The present study aims to confirm these results, initiates with only 16 samples, studying 26 more aneurysms.

Mots clés: Cerebral aneurysm; stiffness; rupture; mechanical identification

Domaines: Biomécanique [physics.med-ph]

Hervé Brunel, Dominique Ambard, H. Dufour, P. H. Roche, Vincent Costalat, et al.. Relationship between cerebral aneurysm wall stiffness and rupture risk. Computer Methods in Biomechanics and Biomedical Engineering, 2017, 20 (sup1), pp.33 - 34. ⟨10.1080/10255842.2017.1382847⟩. ⟨hal-01669020⟩