5-HT4 receptors, a place in the sun: act two

Joël Bockaert (1) , Sylvie Claeysen (1) , Valerie Compan (2, 3) , Aline Dumuis (1)

1 IGF - Institut de Génomique Fonctionnelle
2 BRAINS' Laboratory_LSCO - Brain, Addiction, Anorexia & Innovation in Sciences_Laboratoire des Sciences des Cerveaux en Occitanie UNIMES
3 UNIMES - Université de Nîmes

5-HT4 receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT4 receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT4 receptor drugs have been commercialized. Therefore, the hope that 5-HT4 receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT4 receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.

Domaines: Neurobiologie

Joël Bockaert, Sylvie Claeysen, Valerie Compan, Aline Dumuis. 5-HT4 receptors, a place in the sun: act two. Current Opinion in Pharmacology, 2011, 11 (1), pp.87-93. ⟨10.1016/j.coph.2011.01.012⟩. ⟨hal-01667589⟩