Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives

Abstract : A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds..
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Submitted on : Wednesday, December 13, 2017 - 9:54:29 AM
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Zohra Benfodda, Vanessa Fritz, Corinne Henriquet, Caterina Fattorusso, Gerardo Cebrian-Torrejon, et al.. Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives. Medicinal Chemistry, Bentham Science Publishers, 2017, 7 (9), pp.257-267. ⟨10.4172/2161-0444.1000466⟩. ⟨hal-01662364⟩

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