Algal toxins and producers in the marine waters of Qatar, Toxicon, vol.122, pp.54-66, 2016. ,
Mammalian nicotinic acetylcholine receptors: from structure to function, Physiol. Rev, vol.89, pp.73-120, 2009. ,
Toxic strains of the Alexandrium ostenfeldii complex in southern South America, Harmful Algae, vol.37, pp.100-109, 2014. ,
The globally distributed genus Alexandrium: multifaceted roles in marine ecosystems and impacts on human health, Harmful Algae, vol.14, pp.10-35, 2012. ,
The emergent marine dinoflagellate toxins spirolides and gymnodimines target nicotinic acetylcholine receptors, Biol. Res, vol.42, p.118, 2009. ,
Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A, J. Am. Chem. Soc, vol.133, pp.10499-10511, 2011. ,
Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins, Anal. Chem, vol.84, pp.10445-10453, 2012. ,
The neurotoxic effect of 13,19-didesmethyl and 13-desmethyl spirolide C phycotoxins is mainly mediated by nicotinic rather than muscarinic acetylcholine receptors, Toxicol. Sci, vol.147, pp.156-167, 2015. ,
Marine toxins with spiroimine rings: total synthesis of pinnatoxin A, Eur. J. Org. Chem, pp.5743-5765, 2010. ,
Toxic Alexandrium peruvianum (Balech and de Mendiola) Balech and Tangen in Narragansett Bay, Harmful Algae, vol.19, pp.92-100, 2012. ,
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism, Proc. Natl Acad. Sci. USA, vol.107, pp.6076-6081, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00464306
Marine macrocyclic imines, pinnatoxins A and G: Structural determinants and functional properties to distinguish neuronal a7 from muscle a1(2)bcd nAChR, Structure, vol.23, pp.1106-1115, 2015. ,
Crystal structure of an AChbinding protein reveals the ligand-binding domain of nicotinic receptors, Nature, vol.411, pp.269-276, 2001. ,
Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes, Annu. Rev. Pharmacol. Toxicol, vol.20, pp.15-43, 1980. ,
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures, Neuron, vol.41, pp.907-914, 2004. ,
Spirolide composition of micro-extracted pooled cells isolated from natural plankton assemblages and from cultures of the dinoflagellate Alexandrium ostenfeldii, Nat. Toxins, vol.7, pp.197-206, 1999. ,
The marine dinoflagellate Alexandrium ostenfeldii (Dinophyceae) as the causative organism of spirolide shellfish toxins, Phycologia, vol.39, pp.67-74, 2000. ,
Nicotinic receptors at the amino acid level, Annu. Rev. Pharmacol. Toxicol, vol.40, pp.431-458, 2000. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01719004
The dinoflagellate toxin 20-methyl spirolide-G potently blocks skeletal muscle and neuronal nicotinic acetylcholine receptors, Toxins, vol.8, p.249, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01443823
The marine cytotoxin portimine is a potent and selective inducer of apoptosis, Apoptosis, vol.21, pp.1447-1452, 2016. ,
A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems, ALTEX, vol.30, pp.487-545, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00914469
) 6,6-Spiroimine analogs of (-)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors, Org. Biomol. Chem, vol.9, pp.8112-8118, 2011. ,
Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: a potent tool for expanding functional information, Prog. Neurobiol, vol.88, pp.32-40, 2009. ,
Assignment of the relative stereochemistry of the spirolides, macrocyclic toxins isolated from shellfish and from the cultured dinoflagellate Alexandrium ostenfeldii, Tetrahedron, vol.57, pp.8659-8666, 2001. ,
Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes, Anal. Biochem, vol.403, pp.102-107, 2010. ,
Neural injury biomarkers of novel shellfish toxins, spirolides: a pilot study using immunochemical and transcriptional analysis, Neurotoxicology, vol.24, pp.593-604, 2003. ,
Morphology, phylogenetic position, and ecophysiology of Alexandrium ostenfeldii (Dinophyceae) from the Bohai Sea, China. J. Syst. Evol, vol.49, pp.609-616, 2011. ,
Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: isolation, structure, biological activity and synthesis, Nat. Prod. Rep, vol.27, pp.1350-1366, 2010. ,
Bloom and toxin dynamics of Alexandrium ostenfeldii in a shallow embayment at the SW coast of Finland, northern Baltic Sea, Harmful Algae, vol.15, pp.91-99, 2012. ,
Identification of gymnodimine D and presence of gymnodimine variants in the dinoflagellate Alexandrium ostenfeldii from the Baltic Sea, Toxicon, vol.112, pp.68-76, 2016. ,
Comparison of acetylcholine receptor interactions of the marine toxins, 13-desmethyl spirolide C and gymnodimine, Neuropharmacology, vol.62, pp.2239-2250, 2012. ,
Comparative morphology and molecular phylogenetic analysis of three new species of the genus Karenia (Dinophyceae) from New Zealand, J. Phycol, vol.40, pp.165-179, 2004. ,
Neuromuscular blocking activity of pinnatoxins E, F and G, Toxicon, vol.76, pp.214-220, 2013. ,
, , 2015.
target multiple nicotinic receptor subtypes, J. Neurochem, vol.135, pp.479-491 ,
Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon, Toxicon, vol.75, pp.16-26, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00919909
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal a7-nicotinic acetylcholine receptor, EMBO J, vol.28, pp.3040-3051, 2009. ,
Characterization of biologically inactive spirolides E and F: identification of the spirolide pharmacophore, Tetrahedron Lett, vol.37, pp.7671-7674, 1996. ,
Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum, J. Nat. Prod, vol.59, pp.1010-1014, 1996. ,
Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media, J. Org. Chem, vol.77, pp.10435-10440, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00756265
The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity, J. Neurochem, vol.107, pp.952-963, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00316051
Enantioselective total synthesis of the marine toxin (-)-gymnodimine employing a Barbier-type macrocyclization, Angew. Chem. Int. Ed, vol.48, pp.7402-7405, 2009. ,
Total synthesis of the spirocyclic imine marine toxin (-)-gymnodimine and an unnatural C4-epimer, J. Am. Chem. Soc, vol.133, pp.19844-19856, 2011. ,
Phylogenetic relationships, morphological variation, and toxin patterns in the Alexandrium ostenfeldii (Dinophyceae) complex: implications for species boundaries and identities, J. Phycol, vol.50, pp.81-100, 2014. ,
Diverse seed banks favour adaptation of microalgal populations to future climate conditions, Environ. Microbiol, vol.18, pp.679-691, 2016. ,
Spiroprorocentrimine, a novel macrocyclic lactone from a benthic Prorocentrum sp. of Taiwan, Tetrahedron Lett, vol.42, pp.1713-1716, 2001. ,
Analysis of the action of gymnodimine-A and 13-desmethyl spirolide C on the mouse neuromuscular system in vivo, Toxicon, vol.75, pp.27-34, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00859280
Total synthesis and stereochemistry of pinnatoxins B and C, Org. Lett, vol.8, pp.3327-3330, 2006. ,
Unified total synthesis of pteriatoxins and their diastereomers, J. Am. Chem. Soc, vol.128, pp.7463-7465, 2006. ,
Total synthesis of pinnatoxin A, J. Am. Chem. Soc, vol.120, pp.7647-7648, 1998. ,
Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: new procedure for ion channel studies, Methods Mol. Biol, vol.322, pp.347-355, 2006. ,
New analogue of gymnodimine from a Gymnodinium species, J. Agric. Food Chem, vol.48, pp.1373-1376, 2000. ,
Gymnodimine C, an isomer of gymnodimine B, from Karenia selliformis, J. Agric. Food Chem, vol.51, pp.4838-4840, 2003. ,
Diversity of vertebrate nicotinic acetylcholine receptors, Neuropharmacology, vol.56, pp.237-246, 2009. ,
Cyclic imines: an insight into this emerging group of bioactive marine toxins, Phycotoxins: Chemistry and Biochemistry (Botana L. M, pp.319-335, 2007. ,
Cyclic imine toxins: chemistry, origin, metabolism, pharmacology, toxicology, and detection, Seafood and Freshwater Toxins, pp.951-990, 2014. ,
Spirolides and cyclic imines: toxicological profile, pp.193-217, 2015. ,
X-ray structure of the human a4b2 nicotinic receptor, Nature, vol.538, pp.411-415, 2016. ,
Acute toxicity of gymnodimine to mice, Toxicon, vol.44, pp.173-178, 2004. ,
Acute toxicity of pinnatoxins E, F and G to mice, Toxicon, vol.60, pp.995-999, 2012. ,
Total synthesis of pinnatoxin A, Angew. Chem. Int. Ed, vol.47, pp.7091-7094, 2008. ,
Alternate stoichiometries of a4b2 nicotinic acetylcholine receptors, Mol. Pharmacol, vol.63, pp.332-341, 2003. ,
Vulcanodinium rugosum gen. et sp. nov. (Dinophyceae), un nouveau dinoflagell e marin de la côte m editerran eenne franc ßaise, Cryptogamie, Algologie, vol.32, pp.3-18, 2011. ,
Effects of environmental regimens on the toxin profile of Alexandrium ostenfeldii, Environ. Toxicol. Chem, vol.29, pp.301-310, 2010. ,
First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples, Anal. Chim. Acta, vol.701, pp.200-208, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00637237
Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, Harmful Algae, vol.9, pp.384-389, 2010. ,
Production of pinnatoxins E, F and G by scrippsielloid dinoflagellates isolated from Franklin Harbour, Z. J. Mar. Freshw. Res, vol.45, pp.703-709, 2011. ,
Dinoflagellate Vulcanodinium rugosum N ezan et Chom erat newly identified as the causative organism of pinnatoxins in Australia, Phycologia, vol.50, pp.624-628, 2011. ,
Solid-phase receptor-based assay for the detection of cyclic imines by chemiluminescence, fluorescence, or colorimetry, Anal. Chem, vol.83, pp.5857-5863, 2011. ,
High-throughput receptor-based assay for the detection of spirolides by chemiluminescence, Toxicon, vol.75, pp.35-43, 2013. ,
Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system, Anal. Chem, vol.85, pp.2340-2347, 2013. ,
Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors, Toxicon, vol.91, pp.45-56, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01165541
A formal total synthesis of (+)-pinnatoxin A, Angew. Chem. Int. Ed, vol.43, pp.6505-6510, 2004. ,
Differences in the toxin profiles of Alexandrium ostenfeldii (Dinophyceae) strains isolated from different geographic origins: evidence of paralytic toxin, spirolide, and gymnodimine, Toxicon, vol.103, pp.85-98, 2015. ,
Quantity of the dinoflagellate sxtA4 gene and cell density correlates with paralytic shellfish toxin production in Alexandrium ostenfeldii blooms, Harmful Algae, vol.52, pp.1-10, 2016. ,
Portimine: a bioactive metabolite from the benthic dinoflagellate Vulcanodinium rugosum, Tetrahedron Lett, vol.54, pp.4705-4707, 2013. ,
Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate, Tetrahedron Lett, vol.55, pp.5508-5510, 2014. ,
Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal a7 nicotinic receptor, J. Biol. Chem, vol.272, pp.24279-24286, 1997. ,
Acetylcholine-binding protein engineered to mimic the a4-a4 binding pocket in a4b2 nicotinic acetylcholine receptors reveals interface specific interactions important for binding and activity, Mol. Pharmacol, vol.88, pp.697-707, 2015. ,
Structural studies of nicotinic acetylcholine receptors: using acetylcholinebinding protein as a structural surrogate, Basic Clin. Pharmacol. Toxicol, vol.118, pp.399-407, 2016. ,
A dinoflagellate producer of pinnatoxin G, isolated from sub-tropical Japanese waters, Harmful Algae, vol.10, pp.702-705, 2011. ,
The absolute stereochemistry of the New Zealand shellfish toxin gymnodimine, Tetrahedron Lett, vol.38, pp.4889-4890, 1997. ,
Total synthesis of (+)-pinnatoxin A, J. Am. Chem. Soc, vol.130, pp.3774-3776, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00634136
Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins, Nat. Prod. Rep, vol.32, pp.411-435, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01178830
, , p.896, 2016.
Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex, Harmful Algae, vol.26, pp.52-59, 2013. ,
Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions, Biochemistry, vol.45, pp.8894-8902, 2006. ,
Prorocentrolide, a toxic nitrogenous macrocycle from a marine dinoflagellate, Prorocentrum lima, J. Am. Chem. Soc, vol.110, pp.7876-7877, 1988. ,
Morphogenetic diversity and biotoxin composition of Alexandrium (Dinophyceae) in Irish coastal waters, Harmful Algae, vol.7, pp.782-797, 2008. ,
Assembly of nicotinic and other Cys-loop receptors, J. Neurochem, vol.116, pp.734-741, 2011. ,
Characterization of multiple isolates from an Alexandrium ostenfeldii bloom in The Netherlands, Harmful Algae, vol.49, pp.94-104, 2015. ,
Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications, Tetrahedron Lett, vol.52, pp.4243-4246, 2011. ,
Detection of gymnodimine A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization, Anal. Chem, vol.81, pp.2708-2714, 2009. ,
Human muscarinic acetylcholine receptors are a target of the marine toxin 13-desmethyl C spirolide, Chem. Res. Toxicol, vol.23, pp.1753-1761, 2010. ,