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Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection

Jean Roman 1 Nathalie Jarroux 1 Gilles Patriarche 2 Olivier Français 3 Juan Pelta 1 Bruno Le Pioufle 4 Laurent Bacri 1
1 LAMBE - Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
2 C2N - Centre de Nanosciences et de Nanotechnologies [Marcoussis]
3 ESYCOM - Electronique, Systèmes de communication et Microsystèmes
4 SATIE-BIOMIS - Bio-MIcroSystèmes et BioSensors
SIAME - Systèmes d'Information et d'Analyse Multi-Echelles
Abstract : Electrical detection based on single nanopores is an efficient tool to detect biomolecules, particles and study their morphology. Nevertheless the surface of the solid-state membrane supporting the nanopore should be better controlled. Moreover, nanopore should be integrated within microfluidic architecture to facilitate control fluid exchanges. We built a reusable microfluidic system integrating a decorated membran, rendering the drain and refill of analytes and buffers easier. This process enhances strongly ionic conductance of the nanopore and its lifetime. We highlight the reliability of this device by detecting gold nanorods and spherical proteins.
Keywords : nanopore functionalization solid-state nanopore polymer brush
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Journal articles
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https://hal.archives-ouvertes.fr/hal-01661723
Contributor : Bruno Le Pioufle <>
Submitted on : Tuesday, December 12, 2017 - 10:40:50 AM
Last modification on : Wednesday, July 7, 2021 - 3:14:02 PM

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CNRS | UNIV-CERGY | UNIV-EVRY | ENS-CACHAN | CNAM | SATIE | UPEC-UPEM | IFSTTAR | LAMBE | SATIE-SIAME | SATIE-BIOMIS | ESYCOM | ESIEE-PARIS | UNIV-HESAM | UP-SCIENCES | CY-TECH-SE | CEA | CEA-UPSAY | ENS-PARIS-SACLAY | GS-ENGINEERING | GS-CHIMIE | GS-COMPUTER-SCIENCE

Citation

Jean Roman, Nathalie Jarroux, Gilles Patriarche, Olivier Français, Juan Pelta, et al.. Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2017, 9 (48), pp.41634 - 41640. ⟨10.1021/acsami.7b14717⟩. ⟨hal-01661723⟩

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