Efficacy and safety of bevacizumab-containing neoadjuvant therapy followed by interval debulking surgery in advanced ovarian cancer: Results from the ANTHALYA trial

Roman Rouzier (1) , Sébastien Gouy (2) , Frédéric Selle (1) , Eric Lambaudie (3) , Anne Floquet (4) , Virginie Fourchotte (5) , Christophe Pomel (6, 7) , Pierre-Emmanuel Colombo (8) , Elsa Kalbacher , Sandrine Martin-Francoise , Raffaèle Fauvet (9) , Philippe Follana (10) , Anne Lesoin , Fabrice Lecuru (11) , Youssef Ghazi , Julien Dupin , Elisabeth Chéreau , Sarah Zohar (12) , Paul Cottu (13) , Florence Joly (14)

1 CHU Tenon [AP-HP]
2 IGR - Institut Gustave Roussy
3 IPC - Institut Paoli-Calmettes
4 CEBEDES - Centre Beninois pour l'Environnement et le développement économique et Social
5 Service de Chirurgie Oncologique
6 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
7 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
8 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
9 UMRS893 - Centre de Recherche Saint-Antoine
10 IBDC - Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer
11 HEGP - Hôpital Européen Georges Pompidou [APHP]
12 CRC - Centre de Recherche des Cordeliers
13 Département de Recherche Translationnelle
14 GenoSciencePharma

To investigate whether adding bevacizumab to neoadjuvant carboplatin-paclitaxel (CP) helps achieve optimal debulking, measured by complete resection rate (CRR) at interval debulking surgery (IDS), in patients with initially unresectable International Federation of Gynecology and Obstetrics stage IIIC/IV ovarian, tubal or peritoneal adenocarcinoma.

Mots clés: Bevacizumab; Interval debulking surgery; Neoadjuvant chemotherapy

Domaines: Sciences du Vivant [q-bio]

Roman Rouzier, Sébastien Gouy, Frédéric Selle, Eric Lambaudie, Anne Floquet, et al.. Efficacy and safety of bevacizumab-containing neoadjuvant therapy followed by interval debulking surgery in advanced ovarian cancer: Results from the ANTHALYA trial. European Journal of Cancer, 2017, 70, pp.133 - 142. ⟨10.1016/j.ejca.2016.09.036⟩. ⟨hal-01658616⟩