Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Pradeep J. Nathan , Yen Ying Lim , Rosemary Abbott , Samantha Galluzzi (1) , Moira Marizzoni (1) , Claudio Babiloni (2, 3) , Diego Albani , David Bartres-Faz (4, 5) , Mira Didic (6) , Lucia Farotti , Lucilla Parnetti (7) , Nicola Salvadori , Bernhard W. Müller , Gianluigi Forloni , Nicola Girtler , Tilman Hensch (8) , Jorge Jovicich (9) , Annebet Leeuwis , Camillo Marra (10) , José Luis Molinuevo , Flavio Nobili (11) , Jérémie Pariente (12) , Pierre Payoux (13) , Jean-Philippe Ranjeva (14) , Elena Rolandi , Paolo Maria Rossini (15, 16) , Peter Schönknecht , Andrea Soricelli (17) , Magda Tsolaki (18, 19) , Pieter Jelle Visser (20) , Jens Wiltfang (21) , Jill C. Richardson , Régis Bordet (22) , Olivier Blin (23, 24) , Giovanni B. Frisoni (25) , Pharmacog Consortium

1 IRCCS Fatebenefratelli - Brescia
2 San Raffaele Pisana IRCCS
3 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
4 Departament de Psiquiatria i Psicobiologia Clinica
5 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
6 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
7 Department of Medicine [Perugia, Italy]
8 University Hospital Leipzig = Universitätsklinikum Leipzig
9 UNITN - Università degli Studi di Trento = University of Trento
10 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
11 Clinical Neurophysiology Service, Dept of Endocrinological and Metabolic Sciences, University of Ge
12 Centre Mémoire [CHU de Toulouse]
13 Department of Nuclear Medicine
14 CRMBM - Centre de résonance magnétique biologique et médicale
15 Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA
16 Clinical Neurology
17 SDN - Istituto di Ricerca Diagnostica e Nucleare
18 3rd Department of Neurology
19 Metacohorts Consortium
20 Department of Psychiatry and Neuropsychology, University of Maastricht
21 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
22 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
23 INT - Institut de Neurosciences de la Timone
24 CIC-UPCET - Centre investigation clinique - Unité de pharmacologie clinique et d'évaluations thérapeutiques
25 IRCCS San Giovanni, Laboratory of Epidemiology and Neuroimaging, Brescia

Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.

Mots clés: Alzheimer's disease; Amyloid; CANTAB; Cognitive assessment; CSF; Hippocampal volume; Mild cognitive impairment; Prodromal; Tau

Domaines: Imagerie médicale; Imagerie

Pradeep J. Nathan, Yen Ying Lim, Rosemary Abbott, Samantha Galluzzi, Moira Marizzoni, et al.. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). Neurobiology of Aging, 2017, 53, pp.1--10. ⟨10.1016/j.neurobiolaging.2017.01.013⟩. ⟨hal-01657959⟩