S. E. Raper, M. Grossman, D. J. Rader, J. G. Thoene, B. J. Clark et al., Safety and Feasibility of Liver-Directed Ex Vivo Gene Therapy for Homozygous Familial Hypercholesterolemia, Annals of Surgery, vol.223, issue.2, pp.116-126, 1996.
DOI : 10.1097/00000658-199602000-00002

Y. Borunda, S. Sakakima, Y. Hayashi, A. Yagi, K. Hayakawa et al., New gene therapy strategies for hepatic fibrosis Gene therapy for hepatocellular carcinoma using sonoporation enhanced by contrast agents, World J. Gastroenterol. Cancer Gene Ther, vol.21, issue.12, pp.3813-3825, 2005.

J. W. Castle, K. P. Kent, Y. Fan, K. D. Wallace, C. E. Davis et al., Therapeutic ultrasound: Increased HDL-Cholesterol following infusions of acoustic microspheres and apolipoprotein A-I plasmids, Atherosclerosis, vol.241, issue.1, pp.241-92, 2015.
DOI : 10.1016/j.atherosclerosis.2015.04.817

Y. Utoguchi, S. Negishi, K. Nakagawa, A. Maruyama, M. Delalande et al., Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure Ultrasound and microbubbleassisted gene delivery: recent advances and ongoing challenges, J. Control. Release. Ther. Deliv, vol.142, issue.3, pp.245-250, 2010.

S. Uzbekov, M. Chakravarti, C. Postema, G. Pichon, A. W. Shapiro et al., Ultrasound and microbubble-assisted gene delivery in Achilles tendons: Long lasting gene expression and restoration of fibromodulin KO phenotype, J. Control. Release, vol.156, pp.223-230, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00720602

G. Tawackoli, K. W. Pelled, D. Ferrara, and . Gazit, Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation, J. Control. Release, vol.223, 2016.

C. H. Miao, A. A. Brayman, K. R. Loeb, P. Ye, L. Zhou et al., Ultrasound Enhances Gene Delivery of Human Factor IX Plasmid, Human Gene Therapy, vol.16, issue.7, pp.893-905, 2005.
DOI : 10.1089/hum.2005.16.893

C. D. Anderson, S. Moisyadi, A. Avelar, C. B. Walton, and R. Shohet, Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice, Gene Therapy, vol.91, issue.6, pp.1-47, 2016.
DOI : 10.1073/pnas.94.21.11563

S. Song, M. Noble, S. Sun, L. Chen, A. A. Brayman et al., Efficient Microbubble- and Ultrasound-Mediated Plasmid DNA Delivery into a Specific Rat Liver Lobe via a Targeted Injection and Acoustic Exposure Using a Novel Ultrasound System, Molecular Pharmaceutics, vol.9, issue.8, pp.2187-2196, 2012.
DOI : 10.1021/mp300037t

D. Yang, Y. Gao, K. Tan, Z. Zuo, W. Yang et al., Inhibition of hepatic fibrosis with artificial microRNA using ultrasound and cationic liposome-bearing microbubbles, Gene Therapy, vol.11, issue.12, pp.1140-1148, 2013.
DOI : 10.3748/wjg.v11.i48.7620

M. L. De-temmerman, H. Dewitte, R. E. Vandenbroucke, B. Lucas, C. Libert et al., mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells, Biomaterials, vol.32, issue.34, pp.9128-9135, 2011.
DOI : 10.1016/j.biomaterials.2011.08.024

A. Unger, S. M. Rolland, and . Sullivan, Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration, Gene Ther, vol.7, 2000.

J. P. Christiansen, B. A. French, A. L. Klibanov, S. Kaul, and J. R. Lindner, Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles, Ultrasound in Medicine & Biology, vol.29, issue.12, pp.1759-1767, 2003.
DOI : 10.1016/S0301-5629(03)00976-1

S. Hayashi, M. Mizuno, J. Yoshida, and A. Nakao, Effect of sonoporation on cationic liposomemediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer, Cancer Gene Ther, vol.16, 2009.

J. J. Lawrence and . Rychak, Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles, Ultrasound Med. Biol, vol.36, pp.1907-1918, 2010.

M. Vannan, T. Mccreery, P. Li, Z. Han, E. Unger et al., Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA, Journal of the American Society of Echocardiography, vol.15, issue.3, pp.214-218, 2002.
DOI : 10.1067/mje.2002.119913

C. H. Fan, C. Y. Ting, C. Y. Lin, H. L. Chan, Y. C. Chang et al., Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of, Parkinson's Disease, Sci. Rep, vol.6, p.10, 1038.

L. E. Gracey-maniar, J. M. Maniar, Z. Chen, J. Lu, A. Z. Fire et al., Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level, Molecular Therapy, vol.21, issue.1, pp.131-139, 2013.
DOI : 10.1038/mt.2012.244

E. Riu, Z. Chen, H. Xu, C. He, and M. A. Kay, Histone Modifications are Associated with the Persistence or Silencing of Vector-mediated Transgene Expression In Vivo, Molecular Therapy, vol.15, issue.7, pp.1348-55, 2007.
DOI : 10.1038/sj.mt.6300177

Z. Y. Chen, C. Y. He, A. Ehrhardt, and M. A. Kay, Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo, Molecular Therapy, vol.8, issue.3, pp.495-500, 2003.
DOI : 10.1016/S1525-0016(03)00168-0

M. Quiviger, D. Arfi, L. Mansard, M. Delacotte, D. Pastor et al., High and prolonged sulfamidase secretion by the liver of MPS-IIIA mice following hydrodynamic tail vein delivery of antibiotic-free pFAR4 plasmid vector, Gene Therapy, vol.16, issue.12, pp.1-7, 2014.
DOI : 10.1038/gt.2009.36

G. Byk, D. Scherman, B. Schwartz, and C. Dubertret, Lipopolyamines as transfection agents and pharmaceutical uses thereof, US Pat, vol.6171, pp.612-613, 2001.

B. Thompson, N. Mignet, H. Hofland, D. Lamons, J. Seguin et al., Neutral Postgrafted Colloidal Particles for Gene Delivery, Bioconjugate Chemistry, vol.16, issue.3, pp.608-622, 2005.
DOI : 10.1021/bc040244z

S. Manta, A. Delalande, M. Bessodes, M. F. Bureau, D. Scherman et al., Characterization of Positively Charged Lipid Shell Microbubbles with Tunable Resistive Pulse Sensing (TRPS) Method: A Technical Note, Ultrasound in Medicine & Biology, vol.42, issue.2, pp.42-624, 2016.
DOI : 10.1016/j.ultrasmedbio.2015.10.010
URL : https://hal.archives-ouvertes.fr/hal-01407496

C. Marie, G. Vandermeulen, M. Quiviger, M. Richard, V. Préat et al., pFARs, Plasmids free of antibiotic resistance markers, display high-level transgene expression in muscle, skin and tumour cells, The Journal of Gene Medicine, vol.5, issue.4, pp.323-332, 2010.
DOI : 10.3181/00379727-48-13311

A. Delalande, C. Leduc, P. Midoux, M. Postema, and C. Pichon, Efficient Gene Delivery by Sonoporation Is Associated with Microbubble Entry into Cells and the Clathrin-Dependent Endocytosis Pathway, Ultrasound in Medicine & Biology, vol.41, issue.7, pp.41-1913, 2015.
DOI : 10.1016/j.ultrasmedbio.2015.03.010

C. Chen and M. Borden, Ligand Conjugation to Bimodal Poly(ethylene glycol) Brush Layers on Microbubbles, Langmuir, vol.26, issue.16, pp.13183-94, 2010.
DOI : 10.1021/la101796p
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997633/pdf

{. Feshitan, J. Chen, C. Kwan, J. Borden, and M. , Microbubble size isolation by differential centrifugation, Journal of Colloid and Interface Science, vol.329, issue.2, pp.316-340, 2009.
DOI : 10.1016/j.jcis.2008.09.066

C. Bloquel, C. Trollet, E. Pradines, J. Seguin, D. Scherman et al., Optical imaging of luminescence for in vivo quantification of gene electrotransfer in mouse muscle and knee, BMC Biotechnol, vol.6, issue.16, pp.10-1186, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00081253

. Mignet, Comparative gene transfer between cationic and thiourea lipoplexes, J. Gene Med, vol.12, pp.45-54, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00529308

B. D. Meijering, L. J. Juffermans, A. Van-wamel, R. H. Henning, I. S. Zuhorn et al., Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation, Circulation Research, vol.104, issue.5, pp.679-687, 2009.
DOI : 10.1161/CIRCRESAHA.108.183806

M. Derieppe, K. Rojek, J. Escoffre, B. D. De-senneville, C. Moonen et al., Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: a real-time study, Physical Biology, vol.12, issue.4, pp.46010-46020, 2015.
DOI : 10.1088/1478-3975/12/4/046010
URL : https://hal.archives-ouvertes.fr/hal-01159814

B. Miskey, T. Fletcher, Z. Vandendriessche, Z. Ivics, and . Izsvak, Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

S. N. Vandendriessche, J. H. Waddington, M. K. Mcvey, T. Chuah, and . Vandendriessche, Hyperactive PiggyBac Transposons for Sustained and Robust Liver

A. Keravala, C. L. Chavez, G. Hu, L. E. Woodard, P. E. Monahan et al., Long-term phenotypic correction in factor IX knockout mice by using phiC31 integrase-mediated gene therapy, Gene Therapy, vol.17, issue.8, pp.842-850, 2011.
DOI : 10.1038/mt.2008.294

S. Song, Z. Shen, L. Chen, A. A. Brayman, and C. H. Miao, Explorations of high-intensity therapeutic ultrasound and microbubble-mediated gene delivery in mouse liver, Gene Therapy, vol.605, issue.10, pp.1006-1014, 2011.
DOI : 10.1067/mje.2002.119913