ChemInform Abstract: Asymmetric Synthesis of α,α-Disubstituted Amino Acids by Cycloaddition of (E)-Ketonitrones with Vinyl Ethers

Xiaofei Zhang (1) , Pascale Cividino (2) , Jean-François Poisson (2) , Pavlo Shpak-Kraievskyi (3) , Mathieu Y. Laurent (3) , Arnaud Martel (3) , Gilles Dujardin (3) , Sandrine Py (2)

1 UJF - Université Joseph Fourier - Grenoble 1
2 DCM - SeRCO - Département de Chimie Moléculaire - Synthèse Et Réactivité en Chimie Organique
3 IMMM - Institut des Molécules et Matériaux du Mans

The stereoselectivity of the 1,3-dipolar cycloaddition of (E)-ketonitrones (I) bearing a chiral auxiliary on the nitrogen atom with vinyl ethers is studied.

Mots clés: oxazole derivatives; cycloaddition reactions; diastereoselective syntheses; enantioselective syntheses (incl. cis/trans-isomerism)

Domaines: Chimie

Xiaofei Zhang, Pascale Cividino, Jean-François Poisson, Pavlo Shpak-Kraievskyi, Mathieu Y. Laurent, et al.. ChemInform Abstract: Asymmetric Synthesis of α,α-Disubstituted Amino Acids by Cycloaddition of (E)-Ketonitrones with Vinyl Ethers. ChemInform, 2014, 45 (37), ⟨10.1002/chin.201437144⟩. ⟨hal-01652157⟩