Bevacizumab enhances efficiency of radiotherapy in a lung adenocarcinoma rodent model: Role of αvβ3 imaging in determining optimal window

Stéphanie Becker (1, 2) , Pierre Bohn (2) , Anne-Charlotte Bouyeure-Petit (3) , Romain Modzelewski (2) , David Gensanne (2) , Jean-Michel Picquenot (4) , Bernard Dubray (2) , Pierre Vera (1, 2)

1 Service de médecine nucléaire [Rouen]
2 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle
3 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
4 GPL - Groupe d'étude des proliférations lymphoïdes

Earlier studies indicated that bevacizumab could favorably be combined with radiation. However excessive damage to tumor vasculature can result in radioresistance and clinical data suggest that treatment sequencing may be important when combining bevacizumab with radiation. The aim of this study was to evaluate whether αvβ3 scintigraphic imaging could provide information to determine the optimal combination schedule of bevacizumab and radiotherapy on a lung adenocarcinoma model in mice.

Mots clés: Bevacizumab; Carcinoma; Lung; Radiotherapy; Scintigraphic imaging; αvβ3

Domaines: Cancer

Stéphanie Becker, Pierre Bohn, Anne-Charlotte Bouyeure-Petit, Romain Modzelewski, David Gensanne, et al.. Bevacizumab enhances efficiency of radiotherapy in a lung adenocarcinoma rodent model: Role of αvβ3 imaging in determining optimal window. Nuclear Medicine and Biology, 2015, 42 (12), pp.923 - 930. ⟨10.1016/j.nucmedbio.2015.08.002⟩. ⟨hal-01648096⟩