Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?

C. Lemaitre (1) , S. Dominique (2) , E. Billoud (3) , M. Eliezer (4) , H. Montialoux (1) , M. Quillard (5) , G. Riachi (1) , E. Koning (4) , H. Morisse-Pradier (6) , G. Savoye (1, 7, 8, 9) , C. Savoye-Collet (10, 11) , O. Goria (1)

1 Service d'Hépato-Gastroentérologie [CHU Rouen]
2 Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen]
3 CHU Le Havre
4 Service de Radiologie [CHU Rouen]
5 CHU Rouen
6 Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen]
7 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
8 IRIB - Institute for Research and Innovation in Biomedicine
9 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
10 Service d'Imagerie Médicale [CHU Rouen]
11 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle

Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.

Domaines: Hépatologie et Gastroentérologie

C. Lemaitre, S. Dominique, E. Billoud, M. Eliezer, H. Montialoux, et al.. Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?. Canadian Respiratory Journal / Revue canadienne de pneumologie, 2016, 2016, pp.1 - 8. ⟨10.1155/2016/4592702⟩. ⟨hal-01643994⟩