SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging

Rachel Marion-Letellier , Pierre Bohn (1, 2) , Romain Modzelewski (1, 2) , Pierre Vera (2, 1) , Moutaz Aziz , Charlène Guérin (3) , Guillaume Savoye (4) , Céline Savoye-Collet (5, 1)

1 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle
2 Service de médecine nucléaire [Rouen]
3 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
4 Service d'Hépato-Gastroentérologie [CHU Rouen]
5 Service d'Imagerie Médicale [CHU Rouen]

To assess the feasibility of SPECT-computed tomography (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory characteristics.

Mots clés: Cyclooxygenase-2; SPECT-computed tomography; Crohn’s disease; Colitis; Colitis imaging

Domaines: Traitement des images [eess.IV]; Hépatologie et Gastroentérologie; Sciences du Vivant [q-bio]

Rachel Marion-Letellier, Pierre Bohn, Romain Modzelewski, Pierre Vera, Moutaz Aziz, et al.. SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World Journal of Gastroenterology, 2017, 23 (2), pp.216-223. ⟨10.3748/wjg.v23.i2.216⟩. ⟨hal-01643981⟩