In- and ex-vivo molecular imaging of apoptosis to assess sensitivity of non-small cell lung cancer to EGFR inhibitors using probe-based confocal laser endomicroscopy

Florian Guisier , Pierre Bohn (1, 2) , Maxime Patout , Nicolas Piton (3) , Insaf Farah , Pierre Vera (2, 1) , Luc Thiberville (4, 1) , Mathieu Salaün (4, 1)

1 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle
2 Service de médecine nucléaire [Rouen]
3 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
4 Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen]

Prediction of treatment outcome of non-small cell lung cancer (NSCLC) with EGFR inhibitors on the basis of the genetic analysis of the tumor can be incorrect in case of rare or complex mutations, bypass molecular activation pathways, or pharmacodynamic variations. The aim of this study was to develop an ex vivo and in vivo real-time quantitative imaging test for EGFR inhibitors sensitivity assessment.

Domaines: Cancer

Florian Guisier, Pierre Bohn, Maxime Patout, Nicolas Piton, Insaf Farah, et al.. In- and ex-vivo molecular imaging of apoptosis to assess sensitivity of non-small cell lung cancer to EGFR inhibitors using probe-based confocal laser endomicroscopy. PLoS ONE, 2017, 12 (7), pp.e0180576. ⟨10.1371/journal.pone.0180576⟩. ⟨hal-01643963⟩