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Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions

Agustina Razetti 1 Caroline Medioni 1 Grégoire Malandain 1 Florence Besse 1 Xavier Descombes 1
1 MORPHEME - Morphologie et Images
CRISAM - Inria Sophia Antipolis - Méditerranée , IBV - Institut de Biologie Valrose : U1091, Laboratoire I3S - SIS - Signal, Images et Systèmes
Abstract : Neurite extension is essential to establish complex neuronal circuits during brain development. Neurons extend their axons in a crowded environment to reach target territories and connect to specific partners. Much work has been performed on cultured isolated neurons, focusing on the response of axon growing ends to chemical guidance cues. However, the cellular mechanisms involved in the growth of axon groups in their natural environment (the brain), are still poorly understood. Our objective is to shed light on collective axon growth and branching processes in a complex environment, considering axon-axon mechanical interactions. To do so, we propose a simple mathematical model for axonal elongation that we simulate embedded in a realistic environment.
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https://hal.archives-ouvertes.fr/hal-01643226
Contributor : Agustina Razetti <>
Submitted on : Tuesday, November 21, 2017 - 1:13:35 PM
Last modification on : Tuesday, May 26, 2020 - 6:50:42 PM

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  • HAL Id : hal-01643226, version 1

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Agustina Razetti, Caroline Medioni, Grégoire Malandain, Florence Besse, Xavier Descombes. Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions. Rencontre C@UCA 2017, Jun 2017, Fréjus, France. ⟨hal-01643226⟩

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