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Communication Dans Un Congrès Année : 2017

Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions

Agustina Razetti
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  • PersonId : 978986
Caroline Medioni
Grégoire Malandain
Florence Besse
Xavier Descombes

Résumé

Neurite extension is essential to establish complex neuronal circuits during brain development. Neurons extend their axons in a crowded environment to reach target territories and connect to specific partners. Much work has been performed on cultured isolated neurons, focusing on the response of axon growing ends to chemical guidance cues. However, the cellular mechanisms involved in the growth of axon groups in their natural environment (the brain), are still poorly understood. Our objective is to shed light on collective axon growth and branching processes in a complex environment, considering axon-axon mechanical interactions. To do so, we propose a simple mathematical model for axonal elongation that we simulate embedded in a realistic environment.
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Dates et versions

hal-01643226 , version 1 (21-11-2017)

Identifiants

  • HAL Id : hal-01643226 , version 1

Citer

Agustina Razetti, Caroline Medioni, Grégoire Malandain, Florence Besse, Xavier Descombes. Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions. Rencontre C@UCA 2017, Jun 2017, Fréjus, France. ⟨hal-01643226⟩
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