Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions

Agustina Razetti 1 Caroline Medioni 1 Grégoire Malandain 2 Florence Besse 1 Xavier Descombes 1
1 MORPHEME - Morphologie et Images
CRISAM - Inria Sophia Antipolis - Méditerranée , IBV - Institut de Biologie Valrose : U1091, SIS - Signal, Images et Systèmes
2 EPIDAURE - Medical imaging and robotics
CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : Neurite extension is essential to establish complex neuronal circuits during brain development. Neurons extend their axons in a crowded environment to reach target territories and connect to specific partners. Much work has been performed on cultured isolated neurons, focusing on the response of axon growing ends to chemical guidance cues. However, the cellular mechanisms involved in the growth of axon groups in their natural environment (the brain), are still poorly understood. Our objective is to shed light on collective axon growth and branching processes in a complex environment, considering axon-axon mechanical interactions. To do so, we propose a simple mathematical model for axonal elongation that we simulate embedded in a realistic environment.
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Communication dans un congrès
Rencontre C@UCA 2017, Jun 2017, Fréjus, France
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https://hal.archives-ouvertes.fr/hal-01643226
Contributeur : Agustina Razetti <>
Soumis le : mardi 21 novembre 2017 - 13:13:35
Dernière modification le : mercredi 13 décembre 2017 - 14:30:18

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  • HAL Id : hal-01643226, version 1

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Agustina Razetti, Caroline Medioni, Grégoire Malandain, Florence Besse, Xavier Descombes. Modelling collective axon growth from in vivo data reveals the importance of physical axon-axon interactions. Rencontre C@UCA 2017, Jun 2017, Fréjus, France. 〈hal-01643226〉

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