Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli

Cedric Cagliero (1) , Christian Mouline (1) , Axel Cloeckaert (1) , Sophie Payot (1)

1 UR IASP - Infectiologie Animale et Santé Publique

Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conferring macrolide resistance was observed.

Mots clés: ERYTHROMYCIN RESISTANCE ANTIBIOTICS; FLUOROQUINOLONE; MECHANISMS; MUTATION

Domaines: Sciences du Vivant [q-bio]

Cedric Cagliero, Christian Mouline, Axel Cloeckaert, Sophie Payot. Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli. Antimicrobial Agents and Chemotherapy, 2006, 50 (11), pp.3893-3896. ⟨10.1128/AAC.00616-06⟩. ⟨hal-01637781⟩