ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets

Matija Brozovic 1 Christelle Dantec 1 Justine Dardaillon 1 Delphine Dauga 2 Emmanuel Faure 3, 4 Mathieu Gineste 1 Alexandra Louis 5, 6 Magali Naville 7 Kazuhiro R. Nitta 8 Jacques Piette 1 Wendy Reeves 9 Celine Scornavacca 10 Paul Simion 10 Renaud Vincentelli 11 Maëlle Bellec 12 Sameh Ben Aicha 13 Marie Fagotto 12 Marion Gueroult-Bellone 2 Maximilian Haeussler 14 Edwin Jacox 1 Elijah K. Lowe 15 Mickaël Mendez 8 Alexis Roberge 12 Alberto Stolfi 16 Rui Yokomori 17 C. Titus Brown 15 Christian Cambillau 11 Lionel Christiaen 18 Frédéric Delsuc 10 Emmanuel Douzery 10 Rémi Dumollard 13 Takehiro Kusakabe 19 Kenta Nakai 17 Hiroki Nishida 20 Yutaka Satou 21 Billie Swalla 15 Michael Veeman 9 Jean-Nicolas Volff 22 Patrick Lemaire 1, 3
Abstract : ANISEED (www.aniseed.cnrs.fr) is the main model organism database for tunicates, the sister-group of vertebrates. This release gives access to annotated genomes, gene expression patterns, and anatomical descriptions for nine ascidian species. It provides increased integration with external molecular and taxonomy databases, better support for epigenomics datasets, in particular RNA-seq, ChIP-seq and SELEX-seq, and features novel interactive interfaces for existing and novel datatypes. In particular, the cross-species navigation and comparison is enhanced through a novel taxonomy section describing each represented species and through the implementation of interactive phylogenetic gene trees for 60% of tunicate genes. The gene expression section displays the results of RNA-seq experiments for the three major model species of solitary ascidians. Gene expression is controlled by the binding of transcription factors to cis-regulatory sequences. A high-resolution description of the DNA-binding specificity for 131 Ciona robusta (formerly C. intestinalis type A) transcription factors by SELEX-seq is provided and used to map candidate binding sites across the Ciona robusta and Phallusia mammillata genomes. Finally, use of a WashU Epigenome browser enhances genome navigation, while a Genomicus server was set up to explore microsynteny relationships within tunicates and with vertebrates, Amphioxus, echinoderms and hemichordates.
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Submitted on : Thursday, November 16, 2017 - 6:33:09 PM
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Matija Brozovic, Christelle Dantec, Justine Dardaillon, Delphine Dauga, Emmanuel Faure, et al.. ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets. Nucleic Acids Research, Oxford University Press, 2017, ⟨10.1093/nar/gkx1108⟩. ⟨hal-01636650⟩

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