Thermo-resistance based micro-calorimeter for continuous chemical enthalpy measurements

G Velve Casquillas (1, 2, 3) , F. Bertholle (1) , M. Le Berre (2) , S. Meance (1) , L. Malaquin (1) , Jean-Jacques Greffet (3) , Y. Chen (1, 2)

1 LPN - Laboratoire de photonique et de nanostructures
2 ENS-PSL - École normale supérieure - Paris
3 EM2C - Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion

We present a thermo-resistance based micro-calorimeter using a glass/platinum/PDMS prototyping technology which is more flexible than the existing silicon based technology for lab on a chip device integration. Resistance monitoring and fluid injection techniques are optimized in order to reduce thermal noises and improve the detection sensibility. We used neutralization acid-base reaction to evaluate the device capability in determination of both reagent concentration and reaction enthalpy. We also performed a glucose/glucose oxy-dase enzymatic reaction to illustrate the advantage of using PDMS device for the studies of aerobic reaction.

Mots clés: Microfluidics; Micro-calorimetry; Glass; PDMS; Neutralization; Glucose

Domaines: Optique [physics.optics]

G Velve Casquillas, F. Bertholle, M. Le Berre, S. Meance, L. Malaquin, et al.. Thermo-resistance based micro-calorimeter for continuous chemical enthalpy measurements. Microelectronic Engineering, 2008, 85 (5-6), pp.1367 - 1369. ⟨10.1016/j.mee.2007.12.074⟩. ⟨hal-01630497⟩