Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound

Shaoping Wu (1) , Yaoyao Ning , Yingyong Zhao , Wenji Sun (2) , Serge Thorimbert (3, 4) , Luc Dechoux (3, 4) , Matthieu Sollogoub (4, 5) , Yongmin Zhang (4, 5)

1 SNNU - Shaanxi Normal University
2 Key Laboratory of Resource Biology and Biotechnology
3 CHEMBIO - Chemical Biology
4 IPCM - Institut Parisien de Chimie Moléculaire
5 GOBS - Glycochimie Organique Biologique et Supramoléculaire

Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and choleretic), as well as biotransformation of the gentiopicroside. In addition, attempt towards the total synthesis of gentiopicroside is also presented.

Domaines: Chimie; Sciences du Vivant [q-bio]

Shaoping Wu, Yaoyao Ning, Yingyong Zhao, Wenji Sun, Serge Thorimbert, et al.. Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound. Mini-Reviews in Medicinal Chemistry, 2017, 17 (1), pp.62--77. ⟨10.2174/1389557516666160624124127⟩. ⟨hal-01624680⟩