I. Cavero and H. Holzgrefe, Comprehensive in vitro Proarrhythmia Assay, a 315 novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: a visionary 21st century initiative, Expert Opinion on Drug Safety, vol.13, issue.6, pp.745-758, 2014.

B. Fermini, J. C. Hancox, N. Abi-gerges, M. Bridgland-taylor, K. W. Chaudhary et al., A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm, Journal of Biomolecular Screening, vol.134, issue.1, pp.1-11, 2016.
DOI : 10.1124/jpet.112.192609

T. O-'hara, L. Virág, A. Varró, and Y. Rudy, Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation, PLOS Computational Biology, vol.7, issue.5, pp.1-29, 2011.

Q. Guo, T. Chen, Y. Chen, L. Li, and W. Hu, Microarchitectural design space exploration made fast, Microprocessors and Microsystems, vol.37, issue.1, p.0141933112001433
DOI : 10.1016/j.micpro.2012.07.006

S. S. Mahmoud, Z. M. Hussain, I. Cosic, and Q. Fang, Time-frequency analysis of normal and abnormal biological signals, Biomedical Signal Processing and Control, vol.1, issue.1, 2006.
DOI : 10.1016/j.bspc.2006.02.001

R. J. Martis, U. R. Acharya, H. Adeli, H. Prasad, J. H. Tan et al., Computer aided diagnosis of atrial arrhythmia using dimensionality reduction methods on transform domain representation, Biomedical Signal Processing and Control, vol.13, pp.295-305, 2014.
DOI : 10.1016/j.bspc.2014.04.001

C. Lin, G. Kail, A. Girernus, C. Mailhes, J. Tourneret et al., Sequential beat-to-beat P and T wave delineation and waveform estimation in ECG signals: Block Gibbs sampler and marginalized particle filter, Signal Processing, vol.104, pp.174-187, 2014.
DOI : 10.1016/j.sigpro.2014.03.011

URL : https://hal.archives-ouvertes.fr/hal-01117225

L. N. Sharma, R. K. Tripathy, and S. Dandapat, Multiscale Energy and Eigenspace Approach to Detection and Localization of Myocardial Infarction, IEEE Transactions on Biomedical Engineering, vol.62, issue.7, pp.1827-1837, 2015.
DOI : 10.1109/TBME.2015.2405134

S. Farashi, E. K. Roonizi, and R. Sassi, A multiresolution time-dependent entropy method for QRS complex detection, Biomedical Signal Processing and Control, vol.24, issue.643, pp.63-71, 2016.
DOI : 10.1016/j.bspc.2015.09.008

M. Yochum, C. Renaud, and S. Jacquir, Automatic detection of P, QRS and T patterns in 12 leads ECG signal based on CWT, Biomedical Signal Process- 360 ing and Control, 2016.
DOI : 10.1016/j.bspc.2015.10.011

URL : https://hal.archives-ouvertes.fr/hal-01328478

B. Xi, T. Wang, N. Li, W. Ouyang, W. Zhang et al., Functional Cardiotoxicity Profiling and Screening Using the xCELLigence RTCA Cardio System, Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell- Derived Cardiomyocytes, Assay and Drug Development Technologies, pp.415-421, 2011.
DOI : 10.1016/j.drudis.2008.06.011

I. Giaever and C. R. Keese, Monitoring fibroblast behavior in tissue culture 370 with an applied electric field, Proceedings of the National Academy of Sciences, pp.3761-3764, 1984.

I. Giaever and C. R. Keese, Micromotion of mammalian cells measured 375 electrically, Proceedings of the National Academy of Sciences, pp.7896-7900, 1991.

Y. A. Abassi, B. Xi, W. Zhang, P. Ye, S. L. Kirstein et al., Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects, Chemistry & Biology, vol.16, issue.7, pp.712-723, 2009.
DOI : 10.1016/j.chembiol.2009.05.011

F. A. Atienzar, H. Gerets, K. Tilmant, G. Toussaint, and S. Dhalluin, Evaluation of Impedance-Based Label-Free Technology as a Tool for Pharmacology and Toxicology Investigations, Biosensors, vol.30, issue.1, pp.132-156, 2013.
DOI : 10.1016/j.mrgentox.2012.03.014

J. Wegener, C. R. Keese, I. Giaever-]-c, B. Xiao, G. Lachance et al., Electric Cell???Substrate Impedance Sensing (ECIS) as a Noninvasive Means to Monitor the Kinetics of Cell Spreading to Artificial Surfaces, Experimental Cell Research, vol.259, issue.1, pp.158-166, 2000.
DOI : 10.1006/excr.2000.4919

F. A. Atienzar, K. Tilmant, H. H. Gerets, G. Toussaint, S. Speeckaert et al., The Use of Real-Time Cell Analyzer Technology in Drug Discovery: Defining Optimal Cell Culture Conditions and Assay Reproducibility with Different Adherent Cellular Models, Journal of Biomolecular Screening, vol.16, issue.6, pp.575-587, 2011.
DOI : 10.1177/1087057111402825

Y. A. Abassi, J. A. Jackson, J. Zhu, J. Oconnell, X. Wang et al., Label-free, real-time monitoring of IgE-mediated mast cell activation on microelectronic cell sensor arrays, Journal of Immunological Methods, vol.292, issue.1-2, pp.410-195, 2004.
DOI : 10.1016/j.jim.2004.06.022

J. M. Atienza, J. Zhu, X. Wang, X. Xu, and Y. Abassi, Dynamic Monitoring of Cell Adhesion and Spreading on Microelectronic Sensor Arrays, Journal of Biomolecular Screening, vol.292, issue.8, p.415
DOI : 10.1016/j.jim.2004.06.022

J. L. Sebaugh, Guidelines for accurate ec50/ic50 estimation, Pharmaceuti- 425 cal, Statistics, vol.10, issue.2, pp.128-134, 2011.

L. James, T. Marotti, C. Stowe, H. Farrar, B. Taylor et al., Pharmacokinetics and pharmacodynamics of famotidine in infants Evaluation of drug-induced QT interval prolongation in animal and human Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K+ current, Journal of Clinical Pharmacology Journal of Toxicological Sciences, vol.3827, issue.345, pp.563-567, 1998.

E. Melzer, E. Bardan, Z. Krepel, and S. Bar-meir, Famotidine has no effect on cardiac performance and liver blood flow in the rat, Research in Experimental Medicine, vol.49, issue.Suppl 13, pp.179-184, 1994.
DOI : 10.1161/01.RES.21.2.163

C. Kollmannsberger, D. Soulieres, R. Wong, A. Scalera, R. Gaspo et al., Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects, Canadian Urological Association Journal, vol.1, issue.2S, pp.41-54, 2007.
DOI : 10.5489/cuaj.67

J. Ducroq, H. Moha-ou-maati, S. Guilbot, S. Dilly, E. Laemmel et al., Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for IKs, British Journal of Pharmacology, vol.109, issue.1, pp.93-101, 2010.
DOI : 10.1161/01.CIR.0000133187.74800.B9

URL : https://hal.archives-ouvertes.fr/hal-00561579

L. Guo, L. Coyle, R. M. Abrams, R. Kemper, E. T. Chiao et al., Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model, Toxicological Sciences, vol.136, issue.2, 2013.
DOI : 10.1093/toxsci/kft205

A. Pointon, N. Abi-gerges, M. J. Cross, and J. E. Sidaway, Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity, Toxicological Sciences, vol.132, issue.2, pp.317-326, 2013.
DOI : 10.1093/toxsci/kft005