Vitamin D and Age-Related Macular Degeneration.

Alfredo Garcia Layana , Angelo Maria Minnella , Gerhard Garhöfer , Tariq Aslam , Frank G. Holz (1) , Anita Leys , Rufino Silva (2) , Cécile Delcourt (3) , Eric Souied (4) , Johanna M Seddon

1 Department of Ophthalmology
2 CHUC - Coimbra University Hospital
3 BPH - Bordeaux population health
4 CHIC - Centre Hospitalier Intercommunal de Créteil

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

Mots clés: vitamin D; age-related macular degeneration; angiogenesis; inflammation

Domaines: Organes des sens

Alfredo Garcia Layana, Angelo Maria Minnella, Gerhard Garhöfer, Tariq Aslam, Frank G. Holz, et al.. Vitamin D and Age-Related Macular Degeneration.. Nutrients, 2017, 9 (10), pp.1120. ⟨10.3390/nu9101120⟩. ⟨hal-01617177⟩