Tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate: A mild and convenient Michael acceptor for the synthesis of 2-aminoethylidene-1,1- bisphosphonic acids and their potassium salts

M.V. Shevchuk , Jean-Marc Sotiropoulos (1) , Karinne Miqueu (2) , V.D. Romanenko , V.P. Kukhar

1 IPREM - Institut pluridisciplinaire de recherche sur l'environnement et les matériaux
2 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux

A straightforward synthesis of highly functionalized 2-aminoethylidene-1,1- bisphosphonic acids via the Michael addition of amines to easily available tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate, H2C=C[P(O) (OTMS)2]2, has been described. The potassium salts of the title compounds were also easily achieved in high yield by reacting the Michael adducts with potassium fluoride. © Georg Thieme Verlag Stuttgart - New York.

Domaines: Catalyse; Chimie de coordination; Chimie organique; Polymères; Chimie théorique et/ou physique

M.V. Shevchuk, Jean-Marc Sotiropoulos, Karinne Miqueu, V.D. Romanenko, V.P. Kukhar. Tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate: A mild and convenient Michael acceptor for the synthesis of 2-aminoethylidene-1,1- bisphosphonic acids and their potassium salts. SYNLETT, 2011, 10, pp.1370-1374. ⟨10.1055/s-0030-1260566⟩. ⟨hal-01613245⟩