Impact of a maternal diabetes on embryonic DNA methylation in rabbit blastocyst

K. J. Grybel (1) , Eugénie Canon (2) , J. Knelangen (1) , D. Kradolfer (3) , M. Pendzialek (1) , M. Schindler (1) , J. Guerke (1) , T. Blachere (4, 5, 6) , Murielle Godet (4, 5, 6) , R. Obeid (7) , S. Ulbrich (3) , B. Fischer (1) , Véronique Duranthon (2) , A. Navarrete Santos (1)

1 Department of Anatomy and Cell Biology - Faculty of Medicine
2 BDR - Biologie du Développement et Reproduction
3 Agroscope
4 SBRI - Institut cellule souche et cerveau / Stem Cell and Brain Research Institute
5 UCBL - Université Claude Bernard Lyon 1
6 Université de Lyon
7 Department of Clinical Chemistry

In early pregnancy maternal diabetes leads to delay in embryo development and changes in nutritional and hormonal signals of the uterine environment. The current study focuses on consequences of maternal diabetes on embryonic tissue formation and its DNA methylation.

Domaines: Sciences du Vivant [q-bio]

K. J. Grybel, Eugénie Canon, J. Knelangen, D. Kradolfer, M. Pendzialek, et al.. Impact of a maternal diabetes on embryonic DNA methylation in rabbit blastocyst. 50. Annual Conference of Physiology and Pathology of Reproduction, Deutsche Veterinärmedizinische Gesellschaft. DEU., 2017, Munich, Germany. 64 p., ⟨10.1111/rda.12909⟩. ⟨hal-01606710⟩